Liu Siyuan, Li Fan, Cai Yunjia, Sun Lin, Ren Linan, Yin Mengsha, Cui Huijuan, Pan Yujie, Gang Xiaokun, Wang Guixia
Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Department of Hepatobiliary and Pancreatic Medicine, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Sci Rep. 2025 Mar 19;15(1):9395. doi: 10.1038/s41598-025-94118-7.
This study explores the relationship between gout and metabolic dysfunction-associated steatotic liver disease (MASLD), two metabolic conditions linked to worsening health outcomes. While hyperuricemia's association with MASLD is established, the specific connection between gout and MASLD remains less explored. Using data from the UK Biobank, the study employs COX proportional hazard models, multi-state survival analysis, and Mendelian randomization to assess the independent and mutual risks of gout and MASLD. Findings indicate a mutual risk increase: male gout patients, those younger than 60, and those with high BMI are particularly susceptible to MASLD, while female MASLD patients are at heightened risk for gout. Shared risk factors for both conditions include high BMI, hypertension, diabetes, and hyperuricemia. The study further identifies a bidirectional causal link, with gout leading to MASLD, mediated by gut microbiota Ruminococcaceae and proteins like IL-2 and GDF11, implicating specific metabolic pathways. The findings highlight a clinical and mechanistic correlation, emphasizing the need for targeted interventions to address these overlapping metabolic pathways in future treatments.
本研究探讨痛风与代谢功能障碍相关脂肪性肝病（MASLD）之间的关系，这两种代谢状况都与健康状况恶化有关。虽然高尿酸血症与MASLD的关联已得到证实，但痛风与MASLD之间的具体联系仍有待深入研究。该研究利用英国生物银行的数据，采用COX比例风险模型、多状态生存分析和孟德尔随机化方法，评估痛风和MASLD的独立风险和共同风险。研究结果表明，二者的风险会共同增加：男性痛风患者、60岁以下人群以及高体重指数者尤其易患MASLD，而女性MASLD患者患痛风的风险更高。这两种病症的共同风险因素包括高体重指数、高血压、糖尿病和高尿酸血症。该研究进一步确定了一种双向因果关系，即痛风通过肠道微生物瘤胃球菌科以及白细胞介素-2和生长分化因子11等蛋白质介导导致MASLD，涉及特定的代谢途径。这些发现凸显了临床和机制上的相关性，强调在未来治疗中需要采取针对性干预措施来应对这些重叠的代谢途径。
