埃塞俄比亚西南部2型糖尿病患者的血糖控制及相关因素：一项前瞻性观察研究。

Glycemic control and associated factors in patients with type 2 diabetes in Southwest Ethiopia: a prospective observational study.

作者信息

Garedo Aster Wakjira, Tesfaye Gorfineh Teshome, Tamrat Rahel, Wynendaele Evelien

机构信息

School of Pharmacy, Jimma University, Jimma, Ethiopia.

Drug Quality and Registration (DruQuaR) group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

出版信息

BMC Endocr Disord. 2024 Dec 5;24(1):262. doi: 10.1186/s12902-024-01795-y.

DOI:10.1186/s12902-024-01795-y

PMID:39633380

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11619663/

Abstract

BACKGROUND

Diabetes, a known syndrome marked by hyperglycemia and glucose intolerance, is increasing at an alarming rate worldwide. Over half a billion people worldwide have DM, and most live in low- and middle-income countries. Poor glycemic control is a public health concern in type 2 diabetes mellitus. Glycemic control and identifying factors associated with poor glycemic control can help healthcare providers design programs that improve glycemic control and the quality of services provided to patients.

OBJECTIVES

This study was designed to assess the level of glycemic control and associated factors in patients with type 2 diabetes in Jimma Medical Center, Southwest Ethiopia.

METHODS

This institution-based prospective observational study was conducted among 420 patients with type 2 diabetes at Jimma Medical Center's diabetic clinics. A pretested structured interviewer-administered questionnaire was used to collect data, and a checklist was used to assess patient documents. The data were analyzed using SPSS version 26. The variables linked to poor glycemic control were investigated using binary logistic regression. Variables with p values less than 0.05 were considered statistically significant.

RESULTS

Six-month follow-ups were conducted among 420 patients with type 2 diabetes, among whom 220 (52.38%) were women. The median age of the participants was 54(IQR = 40-60 years old). The proportion of respondents with uncontrolled fasting blood glucose was 58.1%. Sex (AOR = 2.576, 95% CI [2.80-11.479], P = 0.001), age(≥ 60) (AOR = 2.024, 95% CI [1.794-4.646], P = 0.002), diabetes duration > 10 years (AOR = 3.036, 95% CI [2.616-8.306], P = 0.003), type 2 diabetes mellitus on insulin + oral antidiabetic (OADs) (AOR = 2.08, 95% CI [298-3.918], P = 0.004), obesity (AOR = 2.18, 95% CI [(1.218-4.218)], P = 0.003), diabetic complications (AOR = 3.193, 95% CI [2.324-6.05], p = 0.002) and poor self-care practices (AOR = 3.034, 95% CI [5.821-7.02], P = 0.005) were found to be significantly associated with poor glycemic control.

CONCLUSION

At the Jimma Medical Center, the prevalence of poor glycemic control was high. Based on these findings, teaching and counseling provided by healthcare providers should focus on improving diabetes self-care activities, weight reduction, and diabetic complications to achieve good glycemic control.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

糖尿病是一种以高血糖和葡萄糖耐量异常为特征的已知综合征，在全球范围内正以惊人的速度增长。全球超过5亿人患有糖尿病，其中大多数生活在低收入和中等收入国家。血糖控制不佳是2型糖尿病的一个公共卫生问题。血糖控制以及识别与血糖控制不佳相关的因素有助于医疗保健提供者设计改善血糖控制以及提高为患者提供的服务质量的方案。

目的

本研究旨在评估埃塞俄比亚西南部吉马医疗中心2型糖尿病患者的血糖控制水平及相关因素。

方法

这项基于机构的前瞻性观察性研究在吉马医疗中心的糖尿病诊所对420例2型糖尿病患者进行。使用预先测试的结构化访谈问卷收集数据，并使用检查表评估患者文件。数据使用SPSS 26版进行分析。使用二元逻辑回归研究与血糖控制不佳相关的变量。p值小于0.05的变量被认为具有统计学意义。

结果

对420例2型糖尿病患者进行了为期6个月的随访，其中220例（52.38%）为女性。参与者的中位年龄为54岁（四分位间距=40-60岁）。空腹血糖未得到控制的受访者比例为58.1%。性别（调整后比值比=2.576，95%置信区间[2.80-11.479]，P=0.001）、年龄（≥60岁）（调整后比值比=2.024，95%置信区间[1.794-4.646]，P=0.002）、糖尿病病程>10年（调整后比值比=3.036，95%置信区间[2.616-8.306]，P=0.003）、使用胰岛素+口服降糖药（OADs）治疗的2型糖尿病（调整后比值比=2.08，95%置信区间[298-3.918]，P=0.004）、肥胖（调整后比值比=2.18，95%置信区间[(1.218-4.218)]，P=0.003）、糖尿病并发症（调整后比值比=3.193，95%置信区间[2.324-6.05]，P=0.002）和自我护理习惯差（调整后比值比=3.034，95%置信区间[5.821-7.02]，P=0.005）被发现与血糖控制不佳显著相关。