甘油三酯-葡萄糖指数与中国老年人的脂肪性胰腺疾病独立相关。

Triglyceride-glucose index is independently associated with fatty pancreas disease in Chinese elderly.

作者信息

Mi Weinuo, Zhang Yuzhi, Wang Qifeng, Ding Wenbo, Mao Xiaodong, Sun Yu, Li Xingjia, Liu Chao, Xu Shuhang

机构信息

Department of Endocrinology and Metabolism, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Department of Ultrasound, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

BMC Endocr Disord. 2025 Mar 18;25(1):74. doi: 10.1186/s12902-025-01900-9.

DOI:10.1186/s12902-025-01900-9

PMID:40102915

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11916974/

Abstract

OBJECTIVE

To determine the prevalence of fatty pancreas disease (FPD) diagnosed by transabdominal ultrasound in Chinese elderly aged 65 years and above to explore the correlation between triglyceride glucose index (TyG index) and FPD and its severity, and to evaluate the ability of TyG index to identify FPD and its severity.

METHODS

The study population was derived from the Thyroid Diseases in Older Population: Screening, Surveillance, and Intervention (TOPS) study conducted in the iodine-adapted areas of Jiangsu Province from May to July 2021. A total of 567 participants aged 65 years and above in rural areas were included in the final analysis. TyG index was calculated by the established formula: Ln [TG (mg/dL) × FBG (mg/dL)/2]. FPD and the degree of intra-pancreatic fat deposition (IPFD) were diagnosed by abdominal ultrasound. The logistic regression model was performed to determine the correlation between clinical parameters, including TyG index, and FPD and its severity. The diagnostic power of TyG index was assessed by receiver operating characteristic curve (ROC).

RESULTS

Overall, 72.66% (412/567) of subjects had FPD, of which over half had moderate to severe FPD. The proportions of overweight, obesity, NAFLD, and dyslipidemia were significantly higher in the moderate-to-severe FPD group than in the mild FPD group. Multivariate logistic regression showed that TyG index was independently associated with FPD in the elderly population, but was not significantly associated with the severity of IPFD. As the level of TyG index increased, the metabolic disorders in the population worsened and the prevalence of FPD increased significantly. TyG index had a good diagnostic performance for FPD. The combination of BMI or NAFLD and TyG index improved the diagnostic ability for FPD.

CONCLUSION

The prevalence of FPD diagnosed by abdominal ultrasound is high in the elderly aged 65 years and above in rural areas in China. TyG index has good identification of FPD but poor recognition of the severity of IPFD. TyG index, when combined with other clinical parameters, may have more diagnostic advantages.

摘要

目的

通过经腹超声确定中国65岁及以上老年人中脂肪性胰腺疾病（FPD）的患病率，探讨甘油三酯葡萄糖指数（TyG指数）与FPD及其严重程度之间的相关性，并评估TyG指数识别FPD及其严重程度的能力。

方法

研究人群来自2021年5月至7月在江苏省碘适地区开展的老年人群甲状腺疾病：筛查、监测与干预（TOPS）研究。最终分析纳入了567名65岁及以上的农村参与者。TyG指数通过既定公式计算：Ln[甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]。通过腹部超声诊断FPD和胰腺内脂肪沉积（IPFD）程度。采用逻辑回归模型确定包括TyG指数在内的临床参数与FPD及其严重程度之间的相关性。通过受试者工作特征曲线（ROC）评估TyG指数的诊断效能。

结果

总体而言，72.66%（412/567）的受试者患有FPD，其中超过一半患有中度至重度FPD。中度至重度FPD组超重、肥胖、非酒精性脂肪性肝病（NAFLD）和血脂异常的比例显著高于轻度FPD组。多因素逻辑回归显示，TyG指数在老年人群中与FPD独立相关，但与IPFD严重程度无显著关联。随着TyG指数水平升高，人群代谢紊乱加重，FPD患病率显著增加。TyG指数对FPD具有良好的诊断性能。BMI或NAFLD与TyG指数联合可提高对FPD的诊断能力。