Choy D S, Stertzer S, Loubeau J M, Kesseler H, Quilici P, Rotterdam H, Meltzer L
Lasers Surg Med. 1985;5(3):297-308. doi: 10.1002/lsm.1900050312.
The primary concerns in the development of a laser catheter for intravascular use are the potential hazards of vessel wall perforation and distal embolization. We present evidence, using technetium 99-labeled thrombi in two rabbit aortas and one human cadaver coronary artery, that distal embolization does not occur after argon laser recanalization. Also, no vessel wall perforation was observed during recanalization of 15 thrombosed rabbit aortas and 1 inferior vena cava, used because of their extremely thin walls. Laser recanalization of three peripheral arteries with atherosclerotic plaque obstruction, in amputated human legs, showed no evidence of vessel wall perforation. The incidence of vessel wall perforation can be minimized by preferential use of the argon laser, strict maintainance of a coaxial relationship between the laser catheter and the vessel, and exercising care during the actual lasing process. Distal embolization does not appear to be an important consideration.
开发用于血管内的激光导管时主要关注的问题是血管壁穿孔和远端栓塞的潜在风险。我们利用99锝标记的血栓在两只兔主动脉和一条人尸体冠状动脉中进行研究，结果表明氩激光再通术后未发生远端栓塞。此外，在对15条血栓形成的兔主动脉和1条下腔静脉（因其壁极薄而选用）进行再通时，未观察到血管壁穿孔现象。对截肢人腿中三条有动脉粥样硬化斑块阻塞的外周动脉进行激光再通，也未发现血管壁穿孔的迹象。通过优先使用氩激光、严格保持激光导管与血管之间的同轴关系以及在实际激光照射过程中小心操作，可将血管壁穿孔的发生率降至最低。远端栓塞似乎并非重要问题。
