Dries D J, Lawrence P F, Syverud J, Moatamed F, Dixon J
Lasers Surg Med. 1985;5(3):321-6. doi: 10.1002/lsm.1900050314.
Lasers have been advocated to resect atherosclerotic plaques in the cardiovascular system, yet little information is available regarding the effects of laser on the range of occlusive lesions seen in the peripheral arterial tree. This study was conducted to assess the risk of perforation in human cadaveric aorta involved with variable degrees of atherosclerosis. Ten fresh segments of atherosclerotic human aorta were graded for extent of atherosclerosis, then subjected to argon laser energy within 48 hours. Using air as the conduction medium and with the fiber tip 2 or 5 mm from the vessel wall, the argon laser was applied to matched calcified and non-calcified arteries at 3.0-7.0 W and 10.0-13.5 W with energy density identical for matched pairs. Results were compared among segments which were normal in appearance or had only fatty streaks grossly with those with gross regional wall calcification. The mean penetration time (T) for calcified and non-calcified lesions at low and high power outputs was compared. (table; see text) Mean time to perforation and range of time necessary to produce perforation were greater in calcified than non-calcified segments at all power levels employed. These data suggest that atherosclerotic lesions vary in their response to argon laser. The presence of calcium may preclude resection of some plaques and protect against wall perforation.
激光已被提倡用于切除心血管系统中的动脉粥样硬化斑块，但关于激光对外周动脉树中所见闭塞性病变范围的影响，目前可用信息较少。本研究旨在评估不同程度动脉粥样硬化的人体尸体主动脉穿孔的风险。选取10段新鲜的动脉粥样硬化人体主动脉，对动脉粥样硬化程度进行分级，然后在48小时内对其施加氩激光能量。以空气作为传导介质，光纤尖端距血管壁2或5毫米，以3.0 - 7.0瓦和10.0 - 13.5瓦的功率对匹配的钙化和非钙化动脉施加氩激光，匹配对的能量密度相同。将外观正常或仅有脂肪条纹的节段与有明显局部壁钙化的节段的结果进行比较。比较了低功率和高功率输出下钙化和非钙化病变的平均穿透时间（T）。（表格；见正文）在所有使用的功率水平下，钙化节段的平均穿孔时间和产生穿孔所需的时间范围均比非钙化节段更长。这些数据表明，动脉粥样硬化病变对氩激光的反应各不相同。钙的存在可能会妨碍某些斑块的切除，并防止血管壁穿孔。
