Macruz R, Ribeiro M P, Brum J M, Pasqualucci C A, Mnitentag J, Bozinis D G, Marques E, Jatene A D, D'ecourt L V, Armelin E
Lasers Surg Med. 1985;5(3):199-218. doi: 10.1002/lsm.1900050303.
We describe the results of experiments carried out in the arteries of dogs, rabbits, guinea pigs, and humans, normal or atheromatous, calcified, or not, with the application of the argon and CO2 laser, in vitro or in vivo, directly or indirectly. Similarly, we present the results of laser effects when radiation is delivered through a special catheter with the purpose of producing aortic insufficiency, opening pulmonary valvular stenosis, desobstructing carotid and coronary obstruction induced in dogs as well as atheromatous obstructions in human amputated legs. Arterial wall perforation was present in 50% of all cases. We suggest four options in order to diminish this adverse result: (1) the use of coherent optical bundles which will allow the proper guiding of the laser beam, (2) the construction of a special catheter for proper handling of the laser-carrying fiber, (3) a combination of optical and computer programs which will aid to identify calcified regions, and (4) the use of dyes which will be strongly and selectively absorbed by the atheromas and which will thus allow their destruction at low laser powers.
我们描述了在狗、兔子、豚鼠和人类的动脉（正常或动脉粥样硬化、钙化或未钙化）中进行的实验结果，这些实验通过直接或间接、体外或体内的方式应用氩激光和二氧化碳激光。同样，我们展示了通过特殊导管传递辐射时产生的激光效应的结果，目的是制造主动脉瓣关闭不全、打开肺动脉瓣狭窄、解除狗身上诱导的颈动脉和冠状动脉阻塞以及人类截肢腿部的动脉粥样硬化阻塞。在所有病例中，50%出现了动脉壁穿孔。我们提出了四种选择以减少这种不良结果：（1）使用相干光学束，这将允许对激光束进行适当引导；（2）构建一种特殊导管，用于妥善处理携带激光的光纤；（3）光学和计算机程序相结合，这将有助于识别钙化区域；（4）使用能被动脉粥样硬化强烈且选择性吸收的染料，从而在低激光功率下实现对其破坏。
