Jing Yubo, Wang Yiyang, Li Yongxiang, Huang Xinzhu, Wang Junyi, Yelihamu Dlraba, Guo Chenming
Department of Breast Surgery, Center of Digestive and Vascular, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Transl Cancer Res. 2025 Feb 28;14(2):881-906. doi: 10.21037/tcr-24-1291. Epub 2025 Feb 26.
Centromere protein N (), a member of the centromere protein family, contributes to ribonucleic assembly, mitosis progression, and chromosome separation. manifests a close link with the occurrence and progression of several malignant cancers, but there is no pan-cancer study on , and we aim to ascertain the connection between and human cancer prognosis and immunotherapy.
The function in multiple malignant tumors was comprehensively investigated with data from The Cancer Genome Atlas (TCGA) and integrated Gene Expression Omnibus (GEO) database. We examined the transcriptional level, prognostic effect, diagnostic value, genetic and epigenetic alteration, methylation level, and immunological importance of . Furthermore, this work provided further confirmation of the phenotypic regulating function of in breast cancer (BC) cells.
exhibited significant upregulation in diverse cancer tissues and had different expression patterns across immunological and molecular subgroups in several cancer types. Elevated expression of may correlate with a worse prognosis. effectively differentiates most cancers from healthy tissues. Hypomethylate was shown to be promoter in most cancers. was shown to be connected with levels of different immune cell infiltration. Kyoto Encyclopedia of Genes and Genomes (KEGG) and the Gene Set Enrichment Analysis (GSEA) analysis suggested that may mediate neutrophil extranuclear trap formation, cell cycle, and P53 signaling pathways in cancer. studies showed that the overexpression of promotes the proliferation, invasion, and migration of BC cells, while concurrently inhibiting their apoptosis.
may operate as a novel predictive indicator and molecular target for targeted therapy in pan-cancer. Significantly, contributed to controlling the BC growth and advancement.
着丝粒蛋白N（CENPN）是着丝粒蛋白家族的成员之一，有助于核糖核酸组装、有丝分裂进程和染色体分离。CENPN与多种恶性肿瘤的发生和发展密切相关，但目前尚无关于CENPN的泛癌研究，我们旨在确定CENPN与人类癌症预后和免疫治疗之间的联系。
利用来自癌症基因组图谱（TCGA）和综合基因表达 omnibus（GEO）数据库的数据，全面研究了CENPN在多种恶性肿瘤中的功能。我们检测了CENPN的转录水平、预后作用、诊断价值、基因和表观遗传改变、甲基化水平以及免疫重要性。此外，这项工作进一步证实了CENPN在乳腺癌（BC）细胞中的表型调节功能。
CENPN在多种癌症组织中显著上调，并且在几种癌症类型的免疫和分子亚组中具有不同的表达模式。CENPN表达升高可能与较差的预后相关。CENPN能有效区分大多数癌症与健康组织。在大多数癌症中，CENPN启动子显示为低甲基化。CENPN与不同免疫细胞浸润水平相关。京都基因与基因组百科全书（KEGG）和基因集富集分析（GSEA）表明，CENPN可能介导癌症中的中性粒细胞胞外陷阱形成、细胞周期和P53信号通路。体外研究表明，CENPN的过表达促进BC细胞的增殖、侵袭和迁移，同时抑制其凋亡。
CENPN可能作为泛癌靶向治疗的新型预测指标和分子靶点。重要的是，CENPN有助于控制BC的生长和进展。
