Duan Lanzhi, Zeng Rui, Wang Jiang, Hu Sisi, Wang Weiye
Department of Public Health, School of Basic Medical Sciences, Jinggangshan University, Ji'an, Jiangxi, China.
School of Clinical Medicine, Jinggangshan University, Ji'an, Jiangxi, China.
Front Nutr. 2025 Mar 4;12:1523171. doi: 10.3389/fnut.2025.1523171. eCollection 2025.
Existing studies on the association between the composite dietary antioxidant index (CDAI) and all-cause mortality are controversial. We aimed to analyze the association of CDAI with all-cause mortality, and determine the influence of gender on this association.
The data of adult participants (age ≥ 18) from the National Health and Nutrition Examination Survey (NHANES) cycles spanning 2001 to 2018 were analyzed. The NHANES-issued identifiers for participants enabled the linkage of data from the NHANES Public Use Linked Mortality File.
The study encompassed a sample of 15,651 individuals. The mean CDAI was 0.52 ± 6.06. The restricted cubic spline revealed that the hazard ratio (HR) of all-cause mortality decreased significantly with increasing CDAI. However, this negative association existed only when the CDAI was less than 5. Multivariate Cox regression analysis showed that compared to the first CDAI quartile, the HR of all-cause mortality was significantly decreased in the third and fourth quartiles (both < 0.001), and the -value of the trend test was <0.001. In the subgroup analysis, a notably strong negative association between CDAI and the risk of all-cause mortality was only observed in men ( for interaction <0.001).
Higher CDAI is associated with a reduced risk of all-cause mortality exclusively in adult males, underscoring the substantial influence of gender on this relationship.
关于复合膳食抗氧化指数（CDAI）与全因死亡率之间关联的现有研究存在争议。我们旨在分析CDAI与全因死亡率的关联，并确定性别对这种关联的影响。
分析了2001年至2018年美国国家健康与营养检查调查（NHANES）各周期中成年参与者（年龄≥18岁）的数据。NHANES为参与者发放的标识符使得能够将来自NHANES公共使用关联死亡率文件的数据进行链接。
该研究纳入了15651名个体的样本。CDAI的平均值为0.52±6.06。受限立方样条显示，全因死亡率的风险比（HR）随着CDAI的增加而显著降低。然而，这种负相关仅在CDAI小于5时存在。多变量Cox回归分析表明，与CDAI第一四分位数相比，第三和第四四分位数的全因死亡率HR显著降低（均<0.001），趋势检验的P值<0.001。在亚组分析中，仅在男性中观察到CDAI与全因死亡风险之间存在显著的强负相关（交互作用P<0.001）。
较高的CDAI仅与成年男性全因死亡率风险降低相关，这突出了性别对这种关系的重大影响。
