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含有顺式或反式十八碳烯酸浓缩物的膳食脂肪以及肝脏磷脂酰胆碱和磷脂酰乙醇胺的多不饱和脂肪酸模式。

Dietary fats containing concentrates of cis or trans octadecenoates and the patterns of polyunsaturated fatty acids of liver phosphatidylcholine and phosphatidylethanolamine.

作者信息

Lawson L D, Hill E G, Holman R T

出版信息

Lipids. 1985 May;20(5):262-7. doi: 10.1007/BF02534257.

DOI:10.1007/BF02534257
PMID:4010483
Abstract

The effects of the mixed cis- 18:1 isomers and mixed trans- 18:1 isomers present in partially hydrogenated soybean oil (PHSO) upon the patterns of polyunsaturated fatty acids (PUFA) in liver phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were studied in rats fed concentrates of cis- 18:1 or trans- 18:1 isomers isolated as triacylglycerides from PHSO. The cis- 18:1 and trans- 18:1 concentrates were fed at levels equal to those present in PHSO fed at 17.9% of the diet. All diets contained the required amounts of both linoleic and linolenic acids. The trans- 18:1 concentrate was found to suppress the levels of 20:4 omega 6 and 20:3 omega 9, and to increase the levels of 18:2 omega 6 and 20:5 omega 3 in PC and PE. The cis- 18:1 concentrate suppressed 20:4 omega 6 in PC, 20:5 omega 3 in PC and PE, and 18:2 omega 6 in PC, but increased the levels of 20:4 omega 6 in PE, and 20:3 omega 9 in PC and PE. The cis- 18:1 concentrate was more effective than the trans concentrate in suppressing 22:6 omega 3. The trans- 18:1 concentrate was more effective in suppressing 20:4 omega 6. The trans- 18:1 isomers appear to modify PUFA metabolism by inhibition of PUFA synthesis, whereas the cis- 18:1 isomers appear to complete with 2-position fatty acyl transfer and to inhibit omega 3 PUFA acylation.

摘要

在以从部分氢化大豆油（PHSO）中分离出的甘油三酯形式存在的顺式-18:1异构体浓缩物或反式-18:1异构体浓缩物喂养大鼠的实验中，研究了PHSO中存在的混合顺式-18:1异构体和混合反式-18:1异构体对肝脏磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）中多不饱和脂肪酸（PUFA）模式的影响。顺式-18:1和反式-18:1浓缩物的喂食水平与以饮食的17.9%喂食PHSO时其中所含的水平相当。所有饮食都含有所需量的亚油酸和亚麻酸。结果发现，反式-18:1浓缩物会抑制PC和PE中20:4ω6和20:3ω9的水平，并提高18:2ω6和20:5ω3的水平。顺式-18:1浓缩物会抑制PC中的20:4ω6、PC和PE中的20:5ω3以及PC中的18:2ω6，但会提高PE中20:4ω6的水平以及PC和PE中20:3ω9的水平。在抑制22:6ω3方面，顺式-18:1浓缩物比反式浓缩物更有效。在抑制20:4ω6方面，反式-18:1浓缩物更有效。反式-18:1异构体似乎通过抑制PUFA合成来改变PUFA代谢，而顺式-18:1异构体似乎会与2位脂肪酸酰基转移竞争并抑制ω3 PUFA酰化。

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本文引用的文献

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THE EFFECT OF DOSE LEVEL OF ESSENTIAL FATTY ACIDS UPON FATTY ACID COMPOSITION OF THE RAT LIVER.必需脂肪酸剂量水平对大鼠肝脏脂肪酸组成的影响。
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Unusual isomeric polyunsaturated fatty acids in liver phospholipids of rats fed hydrogenated oil.喂食氢化油的大鼠肝脏磷脂中异常的异构多不饱和脂肪酸。
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Decreased formation of porstaglandins derived from arachidonic acid by dietary linolenate in rats.大鼠饮食中的亚麻酸减少了源自花生四烯酸的前列腺素的生成。
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Beta-oxidation of the geometric and positional isomers of octadecenoic acid by rat heart and liver mitochondria.大鼠心脏和肝脏线粒体对十八碳烯酸几何异构体和位置异构体的β-氧化作用。
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