盲眼钟表匠如何摆弄钾离子通道。
How the Blind Watchmaker messed around with potassium channels.
作者信息
Salkoff Lawrence
机构信息
Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
J Gen Physiol. 2025 May 5;157(3). doi: 10.1085/jgp.202513783. Epub 2025 Mar 19.
Abstract
Studies of potassium channel evolution from the Jegla group contribute valuable insights into the evolution of complexity in electrical signaling and the conservation and repurposing of key molecular components throughout evolutionary history.
摘要
杰格拉团队对钾通道进化的研究为电信号复杂性的进化以及关键分子成分在整个进化历史中的保守性和重新利用提供了宝贵的见解。
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本文引用的文献
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Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels.栉水母动物和副同源动物独立进化出功能多样的电压门控钾离子通道。
J Gen Physiol. 2025 May 5;157(3). doi: 10.1085/jgp.202413740. Epub 2025 Mar 18.
2
A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated K channels in animals.对领鞭毛虫的广泛调查修正了动物中 Shaker 家族电压门控 K 通道的进化史。
Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2407461121. doi: 10.1073/pnas.2407461121. Epub 2024 Jul 17.
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Functional analysis of ctenophore Shaker K channels: N-type inactivation in the animal roots.刺胞动物 Shaker K 通道的功能分析：动物根中的 N 型失活。
Biophys J. 2024 Jul 16;123(14):2038-2049. doi: 10.1016/j.bpj.2024.01.027. Epub 2024 Jan 30.
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Dating early animal evolution using phylogenomic data.利用系统基因组学数据追溯早期动物进化。
Sci Rep. 2017 Jun 15;7(1):3599. doi: 10.1038/s41598-017-03791-w.
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K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.钾离子电流多样性由果蝇和小鼠中保守的一个扩展基因家族产生。
Science. 1990 May 4;248(4955):599-603. doi: 10.1126/science.2333511.
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An essential 'set' of K+ channels conserved in flies, mice and humans.在果蝇、小鼠和人类中保守的一组重要钾离子通道。
Trends Neurosci. 1992 May;15(5):161-6. doi: 10.1016/0166-2236(92)90165-5.
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