Woodie Brad R, Holt Isaiah N, Freking Justin A, Harrison Heather C W, Rivin Gabrielle M, Fleischer Alan B
College of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
School of Professional Psychology, Spalding University, Louisville, KY, USA.
Arch Dermatol Res. 2025 Mar 19;317(1):597. doi: 10.1007/s00403-025-04123-z.
Acne vulgaris can negatively impact a patient's quality of life. This study evaluated the psychological and interpersonal perceptions of patients who had received acne treatment. Using data from the National Institutes of Health's All of Us Research Program, we analyzed survey responses from 1,843 participants treated with systemic therapies for acne (reflecting more severe disease) and 1,843 matched participants treated with topical therapies alone. Outcomes included surveys assessing both mental and social health and the prevalence of neuropsychiatric conditions between groups. Compared with those who used only topical therapies, participants treated with systemic therapies for acne experience greater personal and relational difficulties in addition to having higher rates of obsessive-compulsive disorder, personality disorders, anxiety, and depression. These findings were robust in a sensitivity analysis excluding isotretinoin-treated participants. The subset of people with acne who receive systemic therapy comprise a high-risk group for adverse psychological outcomes. We aim to bring greater awareness and sensitivity to these issues among dermatologists and other clinicians managing acne. We also aim to highlight the potential need for neuropsychiatric support in patients with more severe acne.
寻常痤疮会对患者的生活质量产生负面影响。本研究评估了接受痤疮治疗的患者的心理和人际认知。利用美国国立卫生研究院“我们所有人”研究项目的数据，我们分析了1843名接受痤疮全身治疗的参与者（反映更严重的疾病）和1843名仅接受局部治疗的匹配参与者的调查回复。结果包括评估心理和社会健康的调查以及两组之间神经精神疾病的患病率。与仅使用局部治疗的人相比，接受痤疮全身治疗的参与者除了强迫症、人格障碍、焦虑和抑郁的发生率更高外，还经历了更大的个人和人际关系困难。在排除异维A酸治疗参与者的敏感性分析中，这些发现依然可靠。接受全身治疗的痤疮患者亚组是不良心理结果的高危人群。我们旨在提高皮肤科医生和其他治疗痤疮的临床医生对这些问题的认识和敏感度。我们还旨在强调更严重痤疮患者对神经精神支持的潜在需求。
