Tasneem Takfi, Begum Afroza, Chowdhury Mohammad Rocky Khan, Rahman Syed, Macassa Gloria, Manzoor Jasmin, Rashid Mamunur
International Centre for Diarrheal Disease Research (ICDDR, B), Dhaka, Bangladesh.
Department of Maternal and Child Health, National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh.
Front Psychol. 2023 Jul 24;14:1153101. doi: 10.3389/fpsyg.2023.1153101. eCollection 2023.
Depression is a common mental health disorder and one of the major causes of disability. This study aimed at investigating the relationship of acne severity and acne-related quality of life with depressive symptoms, and the mediating effect of acne-related quality of life in a relationship between acne severity and depressive symptoms.
This is a cross-sectional study. Data were collected from acne patients attending a tertiary-level hospital, using a questionnaire that comprised three validated instruments - Investigator's Global Assessment (a single item) scale, Cardiff Acne Disability Index, and Beck Depression Inventory for measuring acne severity, acne-related quality of life, and depressive symptoms, respectively. Logistic regression and linear regression were used to examine the association between acne severity and depressive symptoms and a correlation between the acne-related quality of life and depressive symptoms, respectively. A mediation analysis was also performed to see the mediation effects of acne-related quality of life in a relationship between acne severity and depressive symptoms.
A total of 185 acne patients (155 females, 83.8%) with a mean age was 22.55 ± 8.67 years were included in the study. Adolescents and young adults with severe and moderate acne had 6.14-and 2.28 times higher odds of depression compared to their peers with mild acne, respectively. Patients with low levels of acne-related quality of life had a higher level of depressive symptoms ( = 0.42, < 0.001). The total effect (direct + indirect) was also significant ( = 0.27, 95% CI: 1.29-4.09), implying the effect of acne severity on depression.
The present study suggests that acne severity and acne-related quality of life were associated with depressive symptoms among patients with acne vulgaris. The study also indicates that the relationship between acne severity and depressive symptoms might occur through a chain-mediating effect of acne disability in this population.
抑郁症是一种常见的心理健康障碍，也是导致残疾的主要原因之一。本研究旨在调查痤疮严重程度和痤疮相关生活质量与抑郁症状之间的关系，以及痤疮相关生活质量在痤疮严重程度与抑郁症状关系中的中介作用。
这是一项横断面研究。使用包含三种经过验证的工具的问卷，从一家三级医院的痤疮患者中收集数据——研究者整体评估（单项）量表、卡迪夫痤疮残疾指数和贝克抑郁量表，分别用于测量痤疮严重程度、痤疮相关生活质量和抑郁症状。逻辑回归和线性回归分别用于检验痤疮严重程度与抑郁症状之间的关联以及痤疮相关生活质量与抑郁症状之间的相关性。还进行了中介分析，以观察痤疮相关生活质量在痤疮严重程度与抑郁症状关系中的中介作用。
本研究共纳入185名痤疮患者（155名女性，占83.8%），平均年龄为22.55±8.67岁。与轻度痤疮的同龄人相比，重度和中度痤疮的青少年和年轻人患抑郁症的几率分别高6.14倍和2.28倍。痤疮相关生活质量水平低的患者抑郁症状水平较高（r = 0.42，P < 0.001）。总效应（直接 + 间接）也具有显著性（β = 0.27，95% CI：1.29 - 4.09），这意味着痤疮严重程度对抑郁症有影响。
本研究表明，寻常痤疮患者的痤疮严重程度和痤疮相关生活质量与抑郁症状有关。该研究还表明，在这一人群中，痤疮严重程度与抑郁症状之间的关系可能通过痤疮残疾的链式中介作用发生。
