Channeling Hope in the Expanding Landscape of Therapy for Pulmonary Hypertension: Potential Role for Piezo2.
作者信息
Steppan Jochen, Berkowitz Dan E
机构信息
School of Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (J.S.).
Heersink School of Medicine, Department of Anesthesiology and Perioperative Medicine, Univeristy of Alabama at Birmingham (D.E.B.).
出版信息
Hypertension. 2025 Apr;82(4):598-600. doi: 10.1161/HYPERTENSIONAHA.125.24570. Epub 2025 Mar 19.
Abstract
摘要
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本文引用的文献
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Deficiency of Endothelial Impairs Pulmonary Vascular Angiogenesis and Predisposes Pulmonary Hypertension.内皮细胞缺乏会损害肺血管生成并易患肺动脉高压。
Hypertension. 2025 Apr;82(4):583-597. doi: 10.1161/HYPERTENSIONAHA.124.22948. Epub 2025 Jan 6.
2
Sotatercept: New drug on the horizon of pulmonary hypertension.索他洛尔：肺动脉高压领域的新药。
Vascul Pharmacol. 2024 Dec;157:107442. doi: 10.1016/j.vph.2024.107442. Epub 2024 Nov 19.
3
LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension.LOXL2 抑制可改善肺动脉高压中的肺动脉重构。
Am J Physiol Lung Cell Mol Physiol. 2024 Oct 1;327(4):L423-L438. doi: 10.1152/ajplung.00327.2023. Epub 2024 Jul 16.
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Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double-Blind, Placebo-Controlled Trial.肺动脉高压和阿那曲唑（PHANTOM）：一项随机、双盲、安慰剂对照试验。
Am J Respir Crit Care Med. 2024 Nov 1;210(9):1143-1151. doi: 10.1164/rccm.202402-0371OC.
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Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension.索他洛尔治疗肺动脉高压的3期试验
N Engl J Med. 2023 Apr 20;388(16):1478-1490. doi: 10.1056/NEJMoa2213558. Epub 2023 Mar 6.
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Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome.亚油酸可改善 Angelman 综合征小鼠模型中 PIEZO2 的功能障碍。
Nat Commun. 2023 Mar 1;14(1):1167. doi: 10.1038/s41467-023-36818-0.
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Piezo1, a novel therapeutic target to treat pulmonary arterial hypertension.Piezo1，一种治疗肺动脉高压的新型治疗靶点。
Front Physiol. 2023 Jan 26;14:1084921. doi: 10.3389/fphys.2023.1084921. eCollection 2023.
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