粗球孢子菌球孢子菌素对人多形核白细胞作用的研究。

Studies of the effects of spherulin from Coccidioides immitis on human polymorphonuclear leukocytes.

作者信息

Galgiani J N

出版信息

Mycopathologia. 1985 May;90(2):107-11. doi: 10.1007/BF00436860.

Abstract

The effects of spherule lysate (spherulin) on human polymorphonuclear leukocyte (PMN) function was examined. PMN adherence to glass and capping was increased by spherulin, findings which may account for spherulin's interference with complement-mediated migration through cellulose ester filters. In contrast, PMN attachment to yeast, killing of bacteria, and effects on spherules were virtually unaffected by spherulin, suggesting that it does not directly inhibit PMN antimicrobial function.

摘要

研究了球形体裂解物（球形体素）对人多形核白细胞（PMN）功能的影响。球形体素可增加PMN对玻璃的黏附以及帽形成，这些结果可能解释了球形体素对补体介导的通过纤维素酯滤膜迁移的干扰作用。相比之下，球形体素对PMN与酵母的附着、细菌杀伤以及对球形体的影响几乎没有作用，这表明它不会直接抑制PMN的抗菌功能。