Kaleem Atiya, Sana Aisha, Khan Rafia Usman, Naveed Safila, Qamar Fatima, Zainab Syeda, Iqbal Javed, Sathian Brijesh
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.
Department of Chemistry, NED University of Engineering & Technology, Karachi, Pakistan.
Ther Deliv. 2025 May;16(5):447-457. doi: 10.1080/20415990.2025.2472733. Epub 2025 Mar 20.
This study focuses on the synthesis and evaluation of innovative gold nanoparticles (AuNps) stabilized by short-chain ferulic acid (FA), specifically 4-hydroxy-3-methoxy-cinnamic acid.
We analyzed the size and distribution of FA-TSC-AuNps and FA-NaBH4-AuNps, with the reduction kinetics of Au3 + to Au0. The electronic and optical properties of these AuNps were scrutinized using UV-visible, AFM, and FT-IR.
AFM distinctly showcased spherical particles, average diameters of 4 ± 1 nm for FA-TSC-AuNps and 11 ± 1 nm for FA-NaBH4-AuNps systems. In the DPPH assay, the anti-scavenging activity recorded values of: FA at 15.4% ± 0.32, FA-TSC-AuNps at an impressive 86.8% ± 0.32, and FA-NaBH4-AuNps at 61.5% ± 0.22. The ABTS assay yielded results of: FA at 13%, FA-TSC-AuNps at 70.14%, and FA-NaBH4-AuNps at a remarkable 92.8%. Catalytic investigations revealed that both facilitated the swift conversion of p-nitrophenol to p-aminophenol. Additionally successful chemo sensing capabilities were assessed, particularly in relation to ciprofloxacin antibiotic by distinct shift in color signifies the effective detection capability of both sensory systems for the drug. Moreover, with FA-TSC-AuNps exhibiting significant sensitivity toward aluminum.
These nanoparticles suggest promising avenues for drug system modifications and enhancements, highlighting their multifaceted potential in both catalytic and chemo sensing applications.
本研究聚焦于由短链阿魏酸（FA），即4-羟基-3-甲氧基肉桂酸稳定的新型金纳米粒子（AuNps）的合成与评估。
我们分析了FA-TSC-AuNps和FA-NaBH4-AuNps的尺寸和分布，以及Au3+还原为Au0的动力学。使用紫外可见光谱、原子力显微镜（AFM）和傅里叶变换红外光谱（FT-IR）对这些AuNps的电子和光学性质进行了仔细研究。
AFM清晰地展示了球形颗粒，FA-TSC-AuNps系统的平均直径为4±1nm，FA-NaBH4-AuNps系统的平均直径为11±1nm。在DPPH测定中，抗清除活性记录值如下：FA为15.4%±0.32，FA-TSC-AuNps令人印象深刻地为86.8%±0.32，FA-NaBH4-AuNps为61.5%±0.22。ABTS测定结果为：FA为13%，FA-TSC-AuNps为70.14%，FA-NaBH4-AuNps显著为92.8%。催化研究表明，两者都促进了对硝基苯酚快速转化为对氨基苯酚。此外，还评估了成功的化学传感能力，特别是与环丙沙星抗生素相关的能力，颜色的明显变化表明两个传感系统对该药物都具有有效的检测能力。此外，FA-TSC-AuNps对铝表现出显著的敏感性。
这些纳米粒子为药物系统的修饰和改进提供了有前景的途径，突出了它们在催化和化学传感应用中的多方面潜力。
