一项横断面研究：维持性透析患者血清氧化应激水平与动静脉内瘘成熟之间的关系。
A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients.
作者信息
Wang Mian, Lian JiHong, Kuang Bin, Zhang ChaoHui, Zhang MingHui
机构信息
Department of Vascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510080, China.
Department of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No.106, Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, 510080, China.
出版信息
Open Med (Wars). 2025 Mar 17;20(1):20251149. doi: 10.1515/med-2025-1149. eCollection 2025.
OBJECTIVE
This study was to investigate the relationship between serum superoxide dismutase (SOD) and malondialdehyde (MDA) and arteriovenous fistula (AVF) maturation in maintenance hemodialysis (MHD) patients.
METHODS
A total of 120 MHD patients were divided into a maturation group (72 patients) and a maturation failure group (48 patients). General information and ultrasound data were collected and venous blood was drawn for routine blood tests. General data and serum SOD and MDA were compared. Independent variables with statistically significant ( < 0.05) differences in univariate analysis were included in multivariate logistic regression. Serum SOD and MDA in predicting maturation failure of AVF were analyzed using receiver operating characteristic curves.
RESULTS
The internal diameter of the cephalic vein, internal diameter of the cephalic vein after tourniquet binding, internal diameter of the radial artery, and serum SOD level were lower and serum MDA level was higher in the maturation failure group. Reduced SOD and elevated MDA were independent risk factors for maturation failure of AVF. The area under the curve (AUC) for serum SOD and MDA was 0.68 each. When combined, their AUC for predicting AVF maturation failure was 0.79.
CONCLUSION
Reduced serum SOD and increased MDA are risk factors affecting AVF maturation in MHD patients.
目的
本研究旨在探讨维持性血液透析（MHD）患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）与动静脉内瘘（AVF）成熟之间的关系。
方法
将120例MHD患者分为成熟组（72例）和成熟失败组（48例）。收集一般资料及超声数据，并抽取静脉血进行血常规检查。比较两组的一般资料、血清SOD和MDA水平。将单因素分析中有统计学意义（<0.05）差异的自变量纳入多因素逻辑回归分析。采用受试者工作特征曲线分析血清SOD和MDA对AVF成熟失败的预测价值。
结果
成熟失败组的头静脉内径、扎止血带后头静脉内径、桡动脉内径及血清SOD水平较低，血清MDA水平较高。SOD降低和MDA升高是AVF成熟失败的独立危险因素。血清SOD和MDA的曲线下面积（AUC）均为0.68。两者联合时，预测AVF成熟失败的AUC为0.79。
结论
血清SOD降低和MDA升高是影响MHD患者AVF成熟的危险因素。
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