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胰岛素抵抗相关的灰质体积减少与默认模式网络有关。

Insulin Resistance-related Gray Matter Volume Reduction is Associated with the Default Mode Network.

作者信息

Asano Saki, Ogawa Akitoshi, Osada Takahiro, Oka Satoshi, Nakajima Koji, Oshima Yasushi, Tanaka Sakae, Kaga Hideyoshi, Tamura Yoshifumi, Watada Hirotaka, Kawamori Ryuzo, Konishi Seiki

出版信息

Juntendo Med J. 2025 Jan 30;71(1):32-35. doi: 10.14789/ejmj.JMJ24-0044-OT. eCollection 2025.

DOI:10.14789/ejmj.JMJ24-0044-OT
PMID:40109401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11915748/
Abstract

In this study, we observed that insulin resistance is linked to a reduction in grey matter volume in the default-mode and limbic networks of the cerebral cortex in older adults. Additionally, we found that the paraventricular nucleus of the hypothalamus is significantly functionally connected to these two cortical networks. Our results suggest that the reduction in gray matter volume associated with insulin resistance arises through metabolic homeostasis mechanisms in the hypothalamus.

摘要

在本研究中，我们观察到胰岛素抵抗与老年人大脑皮质默认模式网络和边缘系统网络中的灰质体积减少有关。此外，我们发现下丘脑室旁核与这两个皮质网络显著功能相连。我们的研究结果表明，与胰岛素抵抗相关的灰质体积减少是通过下丘脑的代谢稳态机制产生的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be81/11915748/75124bea4edc/2759-7504-71-1-0032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be81/11915748/e53e29170834/2759-7504-71-1-0032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be81/11915748/75124bea4edc/2759-7504-71-1-0032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be81/11915748/e53e29170834/2759-7504-71-1-0032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be81/11915748/75124bea4edc/2759-7504-71-1-0032-g002.jpg

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本文引用的文献

1
Insulin action in the brain: cell types, circuits, and diseases.脑内胰岛素作用：细胞类型、回路和疾病。
Trends Neurosci. 2022 May;45(5):384-400. doi: 10.1016/j.tins.2022.03.001. Epub 2022 Mar 28.
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Mapping the subcortical connectivity of the human default mode network.绘制人类默认模式网络的皮质下连接图。
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Insulin action in the brain regulates both central and peripheral functions.胰岛素在大脑中的作用调节中枢和外周功能。
Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E156-E163. doi: 10.1152/ajpendo.00642.2020. Epub 2021 May 31.
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Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort.胰岛素抵抗与糖代谢正常的高胰岛素血症期间大脑葡萄糖摄取增加有关：一项大型 PET 队列研究。
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Connectivity-based localization of human hypothalamic nuclei in functional images of standard voxel size.基于连接的方法对标准体素大小功能图像中的人类下丘脑核进行定位。
Neuroimage. 2020 Nov 1;221:117205. doi: 10.1016/j.neuroimage.2020.117205. Epub 2020 Jul 29.
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Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance.室旁核、室周下核和室周下丘脑 IRS4 表达神经元对于正常的能量平衡是必需的。
Sci Rep. 2020 Mar 26;10(1):5546. doi: 10.1038/s41598-020-62468-z.
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Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study.日本城市老年人的骨骼肌功能和长期护理需求（文京健康研究）：一项前瞻性队列研究。
BMJ Open. 2019 Sep 17;9(9):e031584. doi: 10.1136/bmjopen-2019-031584.
8
The Paraventricular Nucleus of the Hypothalamus: Development, Function, and Human Diseases.下丘脑室旁核：发育、功能与人类疾病。
Endocrinology. 2018 Sep 1;159(9):3458-3472. doi: 10.1210/en.2018-00453.
9
Remote control of glucose-sensing neurons to analyze glucose metabolism.远程控制葡萄糖感应神经元以分析葡萄糖代谢。
Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E327-E339. doi: 10.1152/ajpendo.00469.2017. Epub 2018 May 29.
10
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums.2 型糖尿病和阿尔茨海默病中的脑胰岛素抵抗：概念与难题。
Nat Rev Neurol. 2018 Mar;14(3):168-181. doi: 10.1038/nrneurol.2017.185. Epub 2018 Jan 29.