Mahdaoui Mohamed, Naji Yahya, Chraa Mohamed, Kissani Najib, Louhab Nissrine
Neurology, Mohammed VI University Hospital, Marrakesh, MAR.
Neurology, Faculty of Medicine and Pharmacy of Agadir, Ibn Zohr University, Agadir, MAR.
Cureus. 2025 Feb 17;17(2):e79157. doi: 10.7759/cureus.79157. eCollection 2025 Feb.
Ramadan fasting, a religious practice observed by Muslims worldwide, involves abstaining from food, drink, and other specified activities from dawn to sunset. For patients with epilepsy (PWE), fasting during Ramadan presents unique challenges due to potential disruptions in medication schedules, changes in sleep patterns, and alterations in diet, which can influence seizure control. This literature review synthesizes current research on the impact of Ramadan fasting on seizure frequency, quality of life (QoL), and physiological changes in PWE. The review also examines existing clinical guidelines for managing epilepsy during Ramadan and identifies significant gaps in the literature that warrant further investigation. Through a systematic search of three electronic databases, namely PubMed, ScienceDirect, and Google Scholar, relevant studies were identified and analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review reveals a complex relationship between fasting and epilepsy, with some patients experiencing stable or improved seizure control, while others face increased seizure risk. Medication adherence, sleep disruption, and individual patient characteristics are critical in determining outcomes. The findings underscore the importance of personalized care strategies for PWE who wish to fast during Ramadan, including pre-Ramadan consultations, tailored medication regimens, and ongoing monitoring throughout the fasting period. Despite the progress made in understanding the effects of Ramadan fasting on epilepsy, significant gaps remain. The review highlights the need for future studies to assess the long-term impact of fasting, research on diverse patient populations, and the development of evidence-based clinical guidelines. Addressing these gaps is essential to improve the management of epilepsy during Ramadan and ensure that patients can safely observe their religious practices while maintaining optimal seizure control.
斋月禁食是全球穆斯林遵循的一种宗教习俗，包括从黎明到日落期间禁食、禁饮以及避免其他特定活动。对于癫痫患者而言，斋月期间的禁食带来了独特挑战，因为药物服用时间表可能被打乱、睡眠模式发生变化以及饮食改变，这些都会影响癫痫控制。这篇文献综述综合了当前关于斋月禁食对癫痫患者发作频率、生活质量（QoL）和生理变化影响的研究。该综述还审视了斋月期间管理癫痫的现有临床指南，并指出文献中存在的重大空白，这些空白值得进一步研究。通过系统检索三个电子数据库，即PubMed、ScienceDirect和谷歌学术，按照系统评价和Meta分析的首选报告项目（PRISMA）指南识别并分析了相关研究。该综述揭示了禁食与癫痫之间的复杂关系，一些患者的癫痫控制稳定或有所改善，而另一些患者则面临癫痫发作风险增加的情况。药物依从性、睡眠中断和患者个体特征对结果的判定至关重要。研究结果强调了为希望在斋月期间禁食的癫痫患者制定个性化护理策略的重要性，包括斋月前的咨询、量身定制的药物治疗方案以及在禁食期间持续监测。尽管在理解斋月禁食对癫痫的影响方面取得了进展，但仍存在重大空白。该综述强调未来研究需要评估禁食的长期影响、对不同患者群体进行研究以及制定基于证据的临床指南。填补这些空白对于改善斋月期间的癫痫管理以及确保患者能够在安全维持最佳癫痫控制的同时遵守其宗教习俗至关重要。
