植物精油对脂多糖诱导的一氧化氮生成的抑制作用。
Inhibition of LPS-induced NO production by plant essential oils.
作者信息
Li Yonglian, Cao Yingfan, Wong Vincent Kam Wai, Chen Min, Liu Wenfeng, Zhao Suqing
机构信息
Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006 China.
School of Eco-environment Technology, Guangdong Industry Polytechnic University, Guangzhou, 510300 China.
出版信息
Food Sci Biotechnol. 2024 Oct 25;34(6):1443-1451. doi: 10.1007/s10068-024-01738-2. eCollection 2025 Apr.
Essential oils (EOs), derived from medicinal plants, has been reported to possess various bioactivities to treat inflammatory diseases. Therefore, it is urgent to investigate the effect and the mechanism of EOs essential oils as naturally anti-inflammatory agents. The present study indicated thirty-one EOs had different inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Moreover, the most potent EOs against NO production in BV2 cells were chuan-xiong, schizonepeta tenuifolia, lemongrass and zedoary turmeric with IC values of 12.59, 23.12, 22.76 and 21.88 μg/mL, respectively. The further studies revealed that ligustilide, tributyl citrate and longifolene, the main constituents of chuan-xiong EO, schizonepeta tenuifolia EO and zedoary turmeric EO, were responsible for their activities against NO production with IC values of 8.75, 6.05 and 20.32 μg/mL. Above all, theses EOs were confirmed to be promising anti-inflammatory agents.
精油（EOs）源自药用植物，据报道具有多种治疗炎症性疾病的生物活性。因此，迫切需要研究精油作为天然抗炎剂的作用及机制。本研究表明，31种精油对脂多糖（LPS）诱导的一氧化氮（NO）生成具有不同程度的抑制作用。此外，在BV2细胞中对NO生成抑制作用最强的精油是川芎、荆芥、柠檬草和莪术，其IC值分别为12.59、23.12、22.76和21.88μg/mL。进一步研究表明，川芎精油、荆芥精油和莪术精油的主要成分藁本内酯、柠檬酸三丁酯和长叶烯对NO生成具有抑制活性，其IC值分别为8.75、6.05和20.32μg/mL。综上所述，这些精油被证实是有前景的抗炎剂。
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