Hämäläinen Päivi, Viitala Matias, Soilu-Hänninen Merja, Kuusisto Hanna, Niiranen Marja, Avikainen Sari, Puustinen Juha, Ruutiainen Juhani, Ryytty Mervi, Ahvenjärvi Henrik, Björkholm Carl, Hulten Annika
StellarQ Ltd, Turku, Finland.
Finnish Neuro Society, Masku, Finland.
Mult Scler J Exp Transl Clin. 2025 Mar 18;11(1):20552173251325098. doi: 10.1177/20552173251325098. eCollection 2025 Jan-Mar.
To characterize patient-perceived fatigue by using the Finnish Multiple Sclerosis (MS) registry data.
MATERIALS & METHODS: Fatigue was assessed with the Fatigue Severity Scale (FSS), the Fatigue Scale for Motor and Cognitive Functions (FSMC), and the Visual Analogue Scale-Fatigue. Disease severity was evaluated with the Expanded Disability Status Scale and symptoms with the Visual Analogue Scales. Patient reported outcomes (PROs) included the Multiple Sclerosis Neuropsychological Questionnaire, the Euro Quality of Life - 5 dimensions, the 15 D, and the Multiple Sclerosis Impact Scale. For the purposes of the study, patients were classified to those without (FSS ≤ 4) and those with (FSS ≥ 5) fatigue. The FSS scores were correlated with the results of other PROs.
Based on the 512 FSS scores, 47% of the patients reported fatigue (FSS ≥ 5). Fatigue was related to higher disability, lower education, and smoking. FSS correlated significantly with other measures of fatigue, cognitive, and mood symptoms, and was associated with lower Quality of Life.
As an invisible and debilitating symptom fatigue should be evaluated systematically. In the screening, it is important to recognize the characteristics of the different scales. Whereas the FSS may serve as an overall screen, the FSMC may help to identify aspects of cognitive and motor fatigue separately.
利用芬兰多发性硬化症（MS）登记数据描述患者自我感知的疲劳情况。
采用疲劳严重程度量表（FSS）、运动和认知功能疲劳量表（FSMC）以及视觉模拟疲劳量表评估疲劳。用扩展残疾状态量表评估疾病严重程度，用视觉模拟量表评估症状。患者报告结局（PROs）包括多发性硬化症神经心理问卷、欧洲五维健康量表、15D量表和多发性硬化症影响量表。为了本研究的目的，将患者分为无疲劳（FSS≤4）和有疲劳（FSS≥5）两组。FSS评分与其他PROs结果进行相关性分析。
基于512个FSS评分，47%的患者报告有疲劳（FSS≥5）。疲劳与更高的残疾程度、更低的教育水平和吸烟有关。FSS与其他疲劳、认知和情绪症状测量指标显著相关，且与更低的生活质量相关。
作为一种无形且使人衰弱的症状，疲劳应进行系统评估。在筛查中，重要的是要认识到不同量表的特点。虽然FSS可作为一个总体筛查工具，但FSMC可能有助于分别识别认知和运动疲劳的各个方面。
