Hämäläinen Päivi, Leo Vera, Therman Sebastian, Ruutiainen Juhani
Masku Neurological Rehabilitation Centre, The Finnish Neuro Society, Masku, Finland.
Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, Helsinki, Finland.
Brain Behav. 2021 Jun;11(6):e02087. doi: 10.1002/brb3.2087. Epub 2021 May 7.
Cognitive impairment is frequent in multiple sclerosis (MS) as approximately half of the patients manifest some degree of cognitive impairment. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) has been designed for brief cognitive evaluation. The purpose of the study was to validate the BICAMS along with the Finnish versions of one self-rating questionnaire each for cognition and fatigue.
A total of 65 MS patients and 45 healthy controls (HC) were assessed with the BICAMS, the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), and the Fatigue Scale for Motor and Cognitive Functions (FSMC) twice, approximately within nine days.
MS patients scored markedly lower than the HCs on each of the three tests of the BICAMS. Of the patients, 60% scored at least 1.5 SD below the mean of the HCs on at least one test; 49% on the SDMT, 26% on the CVLT-II, and 28% on the BVMT-R. Correlation coefficients for the repeated measurement were between 0.75 and 0.89 for the three tests in the whole study sample. MS patients reported more cognitive symptoms and more fatigue than the HCs. Cronbach's alpha was 0.94 for the MSNQ and 0.98 for the FSMC. Correlation coefficient for the repeated measurement was 0.91 for the MSNQ and between 0.92 and 0.94 for the FSMC scores for the whole study sample.
The present study supports the validity of the Finnish version of the BICAMS. The SDMT was the most sensitive of the three BICAMS tests and showed cognitive impairment in half of the patients. The Finnish versions of the MSNQ and the FSMC proved useful tools in approaching concerns related to cognition and fatigue.
认知障碍在多发性硬化症（MS）中很常见，约一半的患者表现出一定程度的认知障碍。简短国际多发性硬化症认知评估量表（BICAMS）旨在进行简短的认知评估。本研究的目的是验证BICAMS以及芬兰语版的一份认知自评问卷和一份疲劳自评问卷。
对65例MS患者和45名健康对照者（HC）使用BICAMS、多发性硬化症神经心理问卷（MSNQ）和运动与认知功能疲劳量表（FSMC）进行了两次评估，两次评估间隔约九天。
在BICAMS的三项测试中，MS患者的得分均显著低于HC。在患者中，60%在至少一项测试中的得分比HC的平均分低至少1.5个标准差；符号数字模式测验（SDMT）为49%，加利福尼亚语言学习测验第二版（CVLT-II）为26%，本顿视觉保持测验修订版（BVMT-R）为28%。在整个研究样本中，三项测试的重复测量相关系数在0.75至0.89之间。MS患者报告的认知症状和疲劳比HC更多。MSNQ的克朗巴哈系数为0.94，FSMC的克朗巴哈系数为0.98。在整个研究样本中，MSNQ的重复测量相关系数为0.91，FSMC得分的重复测量相关系数在0.92至0.94之间。
本研究支持芬兰语版BICAMS的有效性。SDMT是BICAMS三项测试中最敏感的一项，半数患者存在认知障碍。芬兰语版的MSNQ和FSMC被证明是处理与认知和疲劳相关问题的有用工具。
