Irekeola Ahmad Adebayo, Shueb Rafidah Hanim, Engku Abd Rahman Engku Nur Syafirah, Bello Kizito Eneye, Elmi Abdirahman Hussein, Afolabi Hafeez Abiola, Sabour Amal A, Alshiekheid Maha A, Al Kaabi Nawal A, Al-Subaie Maha F, Rabaan Ali A
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Microbiology Unit, Department of Biological Sciences, College of Natural and Applied Sciences, Summit University Offa, Offa, Kwara State, Nigeria.
Pathog Glob Health. 2025 May-Jun;119(3-4):134-146. doi: 10.1080/20477724.2025.2479971. Epub 2025 Mar 20.
The issue of bacterial resistance remains a significant public health problem, with carbapenem-resistant and having adverse effects on agriculture and healthcare. Nonetheless, the true prevalence of CRE in non-clinical settings in Nigeria is unknown. Thus, for the first time, this study undertook a systematic review and meta-analysis to offer comprehensive data on the prevalence of carbapenem-resistant and in non-clinical isolates from Nigeria. The guideline of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) was followed. Multiple databases were searched for relevant studies and data from eligible studies were analyzed using the random effect model. From 321 retrieved records, 17 were included. The pooled prevalence of carbapenem-resistant was 14.2% (95% CI: 4.6-36.0, = 94.51, < 0.001), which was lower than carbapenem-resistant at 37.8% (95% CI: 13.6-70.2, = 86.48, < 0.001). The prevalence of and was highest in Nasarawa and Ebonyi, with estimates of 85.0% (95% CI: 70.4% - 93.1%) and 80.1% (95% CI: 69.8-87.5%), respectively. The prevalence of . was greater in the South-East region (63.0%) compared with the South-West region (4.5%) of the country. There was a significant variation in the prevalence of these pathogens depending on the sample sources, with a progressive increase observed over time. This study underscores a notable prevalence of carbapenem-resistant pathogens in non-clinical settings, highlighting the imperative for a holistic management approach.
细菌耐药性问题仍然是一个重大的公共卫生问题，碳青霉烯类耐药菌对农业和医疗保健都有不利影响。然而，尼日利亚非临床环境中碳青霉烯类耐药肠杆菌科细菌（CRE）的真实流行情况尚不清楚。因此，本研究首次进行了系统评价和荟萃分析，以提供有关尼日利亚非临床分离株中碳青霉烯类耐药菌和的流行情况的全面数据。遵循了系统评价和荟萃分析的首选报告项目（PRISMA）指南。在多个数据库中检索相关研究，并使用随机效应模型分析符合条件的研究数据。从检索到的321条记录中，纳入了17条。碳青霉烯类耐药菌的合并流行率为14.2%（95%置信区间：4.6-36.0，I²=94.51，P<0.001），低于碳青霉烯类耐药肠杆菌科细菌的37.8%（95%置信区间：13.6-70.2，I²=86.48，P<0.001）。在纳萨拉瓦州和埃邦伊州，碳青霉烯类耐药菌和的流行率最高，估计分别为85.0%（95%置信区间：70.4%-93.1%）和80.1%（95%置信区间：69.8-87.5%）。该国东南部地区（63.0%）的碳青霉烯类耐药菌的流行率高于西南部地区（4.5%）。这些病原体的流行率因样本来源而异，且随时间推移呈逐渐上升趋势。本研究强调了非临床环境中碳青霉烯类耐药病原体的显著流行，突出了采取全面管理方法的必要性。
