McMullan Elena, Joladarashi Darukeshwara, Kishore Raj
Aging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Curr Cardiol Rep. 2025 Mar 20;27(1):73. doi: 10.1007/s11886-025-02225-8.
The rising global prevalence of cardiovascular disease is driving the need for innovative biotherapeutics. Recently, exosomes-extracellular vesicles involved in paracrine signaling have shown promise in aiding heart repair associated with cardiovascular conditions. Their therapeutic potential encompasses several beneficial mechanisms, including anti-fibrosis, anti-inflammation, pro-angiogenesis, anti-oxidation, and anti-apoptosis, all contributing to improved cardiac function. This review provides a comprehensive overview of exosomes and highlights the latest research on their effectiveness in addressing current challenges in regenerative cardiac medicine.
Current approaches revolve around elucidating and enhancing how different cell types, cargo, and delivery methods impact healing in a pathological cardiovascular environment. The emerging field of therapeutic exosome research is promising for cardiac regeneration due to the beneficial effects of exosomal cargo. The expansion of mechanistic knowledge and the optimization of techniques are required before standard clinical application.
心血管疾病在全球的患病率不断上升，这推动了对创新生物疗法的需求。最近，参与旁分泌信号传导的外泌体（细胞外囊泡）在辅助与心血管疾病相关的心脏修复方面显示出前景。它们的治疗潜力包括多种有益机制，如抗纤维化、抗炎、促血管生成、抗氧化和抗凋亡，所有这些都有助于改善心脏功能。本综述全面概述了外泌体，并重点介绍了其在应对再生心脏医学当前挑战方面有效性的最新研究。
当前的方法围绕阐明和增强不同细胞类型、货物和递送方式如何在病理性心血管环境中影响愈合展开。由于外泌体货物的有益作用，治疗性外泌体研究这一新兴领域对心脏再生很有前景。在标准临床应用之前，需要扩展机制知识并优化技术。
