Dong Huan, Qi Xiaoquan
State Key Laboratory of Forage Breeding-by-Design and Utilization, Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.
State Key Laboratory of Forage Breeding-by-Design and Utilization, Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.
Curr Opin Plant Biol. 2025 Jun;85:102701. doi: 10.1016/j.pbi.2025.102701. Epub 2025 Mar 20.
Plant triterpenoids, a vast and diverse group of natural compounds derived from six isoprene units, exhibit an extensive array of structural diversity and remarkable biological activities. In this review, we update the recent research progress in the catalytic mechanisms underlying triterpene synthesis and summarize the current insights into the biosynthetic pathways and regulatory mechanisms of triterpenoids. We emphasize the biosynthesis of pharmacologically active triterpenoids and the role of triterpenoid synthesis in plant growth, development, defense mechanisms, and plant-microbe interactions. This insight review offers a comprehensive perspective on the applications and future avenues of triterpenoid research.
植物三萜类化合物是一类由六个异戊二烯单元衍生而来的庞大而多样的天然化合物，具有广泛的结构多样性和显著的生物活性。在本综述中，我们更新了三萜类化合物合成催化机制的最新研究进展，并总结了目前对三萜类化合物生物合成途径和调控机制的认识。我们强调了具有药理活性的三萜类化合物的生物合成以及三萜类化合物合成在植物生长、发育、防御机制和植物 - 微生物相互作用中的作用。这篇见解性综述为三萜类化合物研究的应用和未来发展方向提供了全面的视角。
