Department of oral pathology, Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, China.
J Oral Pathol Med. 2019 Apr;48(4):321-325. doi: 10.1111/jop.12836. Epub 2019 Feb 18.
Oral submucous fibrosis (OSF) has been reported frequently in India and other countries in South Asia. There are few reports on the clinicopathological features of OSF in China, where OSF is an epidemic. This study analyses the clinicopathological features of OSF in Hunan Province, China.
A total of 674 cases of OSF were collected from July 2013 to August 2018 in Xiangya Stomatological Hospital, Central South University, and gender, age, site, pathological stage, habits, symptoms and associated lesions were recorded.
The male to female ratio was 32.7:1. The average age was 35.23 ± 10.08. The buccal mucosa was the most common site. A total of 99.85% of OSF cases chewed areca nut. Pale mucosa, restricted mouth opening, burning and fibrous bands were common clinical manifestations. Oral leukoplakia (OLK) was the most common associated lesion. The extended duration of chewing areca nut increased the risk of associated lesions (P < 0.05). The risk of OSF associated with OLK decreased with increasing OSF stage (P < 0.05).
The prevalence of OSF in males was higher than that in females, the buccal mucosa was most affected, and chewing areca nut is the most common habit of OSF patients.
口腔黏膜下纤维性变（OSF）在印度和南亚其他国家较为常见。在中国，OSF 是一种流行疾病，有关其临床病理特征的报道较少。本研究分析了中国湖南省 OSF 的临床病理特征。
收集 2013 年 7 月至 2018 年 8 月在中南大学湘雅口腔医院诊断为 OSF 的 674 例患者的临床资料，记录其性别、年龄、部位、病理分期、咀嚼习惯、症状和伴发疾病。
男女比例为 32.7:1，平均年龄为 35.23±10.08 岁，颊黏膜最常见，99.85%的 OSF 患者咀嚼槟榔，常见的临床表现为黏膜苍白、张口受限、烧灼感和纤维条索，最常见的伴发疾病是口腔白斑（OLK）。咀嚼槟榔时间延长会增加伴发疾病的风险（P<0.05），而随着 OSF 分期的增加，OLK 发生 OSF 的风险降低（P<0.05）。
男性 OSF 患病率高于女性，颊黏膜最常受累，咀嚼槟榔是 OSF 患者最常见的习惯。
