Ruampatana Jakavat, Feyera Takele, Yamsrikaew Unchean, Juarjan Methaporn, Homyog Kunaporn, Mekboonsonglarp Wanwimon, Settachaimongkon Sarn, Nuntapaitoon Morakot
Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Animal Veterinary Sciences, Aarhus University, AU-Viborg, Tjele, DK 8830, Denmark.
Comput Struct Biotechnol J. 2025 Feb 27;27:869-878. doi: 10.1016/j.csbj.2025.02.033. eCollection 2025.
an algae-derived source of β-glucan, exhibits prebiotic activity that enhances colostrum quality and improves growth, though the underlying mechanisms remain unclear. This study investigates the effects of supplementation during late gestation and lactation on sow colostrum and milk biomolecular profiles. Sixty-one crossbred sows (Landrace × Yorkshire) were assigned to a standard diet (CON; = 30) or the CON diet supplemented with 1 g/sow/day of (TRT; = 31) from day 85 of gestation until day 21 of lactation. Sow performance, including litter size and weight, was recorded from birth to day 21 of age. Colostrum samples ( = 20; 10 sows/group) were collected within 1 h of farrowing, and milk samples were collected from the same sows on days 3 and 10 of lactation to assess alterations in non-volatile polar metabolites (NVM), fatty acids (FA), and associated metabolic pathways. On average, the litter size at birth was 14.2 ± 2.5 piglets/litter, with no effect of dietary treatment from birth to day 21 of lactation ( > 0.05). However, piglets suckled by TRT sows tended to have higher average daily gain from birth to day 21 of age than those suckled CON sows (191.0 ± 6.7 vs. 173.6 ± 6.8 g/day, = 0.073). Chemometric analysis revealed distinct NVM and FA profiles between the groups, particularly in the colostrum. Although supplementation influenced the contents of multiple metabolites, focus has been given to those that have direct impact on piglet development, including increased colostrum leucine ( = 0.001), threonine ( < 0.001), and N-acetylglucosamine ( = 0.002), enhancing colostrum quality and immunomodulatory potential. Elevated colostrum gamma-linolenic acid ( = 0.047) and arachidonic acid ( = 0.019) levels suggested enhanced immune development. Pathways associated with amino sugars and nucleotide sugars and glucose-related metabolism in colostrum were also modulated. These findings suggest -derived β-glucan as a potential dietary supplement for enhancing sow colostrum quality and piglet growth.
一种源自藻类的β-葡聚糖，具有益生元活性，可提高初乳质量并促进生长，但其潜在机制尚不清楚。本研究调查了在妊娠后期和哺乳期补充[具体物质]对母猪初乳和乳汁生物分子谱的影响。61头杂交母猪（长白猪×约克夏猪）被分配到标准日粮组（对照组；n = 30）或从妊娠第85天至哺乳期第21天，在对照组日粮基础上每头母猪每天补充1 g [具体物质]的试验组（TRT组；n = 31）。记录从出生到21日龄仔猪的生长性能，包括窝产仔数和仔猪体重。在分娩后1小时内采集初乳样本（n = 20；每组10头母猪），并在哺乳期第3天和第10天从同一母猪采集乳汁样本，以评估非挥发性极性代谢物（NVM）、脂肪酸（FA）及相关代谢途径的变化。平均而言，出生时窝产仔数为14.2±2.5头/窝，从出生到哺乳期第21天，日粮处理无显著影响（P>0.05）。然而，TRT组母猪哺乳的仔猪从出生到21日龄的平均日增重往往高于对照组母猪哺乳的仔猪（191.0±6.7 vs. 173.6±6.8 g/天，P = 0.073）。化学计量分析显示，两组之间的NVM和FA谱存在明显差异，尤其是在初乳中。虽然补充[具体物质]影响了多种代谢物的含量，但重点关注了那些对仔猪发育有直接影响的物质，包括初乳中亮氨酸（P = 0.001）、苏氨酸（P<0.001）和N-乙酰葡糖胺（P = 0.002）含量增加，提高了初乳质量和免疫调节潜力。初乳中γ-亚麻酸（P = 0.047）和花生四烯酸（P = 0.019）水平升高表明免疫发育增强。初乳中与氨基糖、核苷酸糖和葡萄糖相关代谢的途径也受到调节。这些发现表明，源自[具体物质]的β-葡聚糖作为一种潜在的日粮补充剂，可提高母猪初乳质量和仔猪生长性能。
