Fuji Yushiro, Matsufuji Hiroshi, Hirai Masami Yokota
RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa 230-0045, Japan.
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-0880, Japan.
Plant Biotechnol (Tokyo). 2024 Sep 25;41(3):231-241. doi: 10.5511/plantbiotechnology.24.0720a.
Phenylethanoid glycosides (PhGs), with a C-C glucoside unit as the basic skeleton, are specialized (secondary) metabolites found in several medicinal plants. As PhGs exhibit various pharmacological activities, they are expected to be used as lead compounds in drug discovery. However, mass-production systems have not yet been established even for acteoside, a typical PhG that is widely distributed in nature (more than 150 species). This review focuses on recent studies on the accumulation and distribution of PhGs in plants, biosynthetic pathways of PhGs, and the bioproduction of PhGs.
苯乙醇苷（PhGs）以碳 - 碳糖苷单元为基本骨架，是在多种药用植物中发现的特殊（次生）代谢产物。由于PhGs具有多种药理活性，它们有望用作药物研发中的先导化合物。然而，即使对于acteoside这种在自然界广泛分布（超过150种植物）的典型PhG，大规模生产系统尚未建立。本综述重点关注PhGs在植物中的积累与分布、PhGs的生物合成途径以及PhGs的生物生产方面的最新研究。
