Nakashima Saki, Sato Kenichiro, Niimi Yoshiki, Toda Tatsushi, Iwatsubo Takeshi
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
JAR Life. 2025 Mar 3;14:100008. doi: 10.1016/j.jarlif.2025.100008. eCollection 2025.
Web-based approach is considered helpful for the research focused on screening and early detection of individuals with preclinical Alzheimer's disease (AD); obtaining sufficient responses is critical to the success of such online study.
This study examined factors influencing response rates to an online survey about disease-modifying drugs for AD among participants in the Japanese Trial-Ready Cohort (J-TRC) webstudy.
This was a retrospective observational study.
Online survey in Japan using Google Forms.
We enrolled the eligible J-TRC webstudy participants who had registered before September 2023. We sent them an invitation e-mail including a questionnaire web address on November-December 2023, in order to conduct an online survey regarding their perceptions of disease-modifying therapy drug that was approved in July 2023, Japan.
We analyzed the impact of mailed day of the week (DOW), participant gender, age, employment status, and educational background with/without response to the invitation, quantified by the odds ratio of response.
Among approximately 10,400 J-TRC web study participants who sent invitation emails, the overall response rate was approximately 20 %, without significant influence depending on the DOW when the survey invitation was sent. Individuals who were older (50s-70s), retired, or had higher education levels were significantly more likely to respond, regardless of the DOW. Differences in response rates by sex/gender were observed, but were largely influenced by the employment status.
In order to improve response rates and enhance data quality, these findings provide valuable insights for optimizing the design of future online studies/surveys in the field of AD and dementia, particularly for targeting cognitively unimpaired middle-aged and older populations.
基于网络的方法被认为有助于针对临床前阿尔茨海默病（AD）个体的筛查和早期检测的研究；获得足够的回复对于此类在线研究的成功至关重要。
本研究调查了影响日本试验就绪队列（J-TRC）网络研究参与者对AD疾病修饰药物在线调查回复率的因素。
这是一项回顾性观察研究。
在日本使用谷歌表单进行在线调查。
我们招募了在2023年9月之前注册的符合条件的J-TRC网络研究参与者。2023年11月至12月，我们向他们发送了一封包含问卷网址的邀请电子邮件，以就他们对2023年7月在日本获批的疾病修饰治疗药物的看法进行在线调查。
我们分析了一周中的邮寄日期（DOW）、参与者性别、年龄、就业状况和教育背景对邀请回复与否的影响，通过回复优势比进行量化。
在发送邀请电子邮件的约10400名J-TRC网络研究参与者中，总体回复率约为20%，发送调查邀请时的DOW对回复率没有显著影响。年龄较大（50多岁至70多岁）、退休或教育水平较高的个体无论DOW如何，回复的可能性显著更高。观察到了按性别划分的回复率差异，但在很大程度上受就业状况影响。
为了提高回复率并提升数据质量，这些发现为优化AD和痴呆领域未来在线研究/调查的设计提供了有价值的见解，特别是针对认知未受损的中老年人群体。
