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纳米与脂质体癌症化疗:药物递送进展及其应用综述

Nano and liposome cancer chemotherapy: A review of advances in drug delivery with applications.

作者信息

Zhang Lianmei, Jin Xinglin

出版信息

Int J Clin Pharmacol Ther. 2025 May;63(5):208-216. doi: 10.5414/CP204715.

DOI:10.5414/CP204715
PMID:40116196
Abstract

The high incidence of malignant tumors continues to pose a significant threat to public health. In recent years, there have been notable advancements in tumor treatment methods, leading to substantial changes in the concepts and clinical approaches to treatment. The primary clinical methods for treating malignant tumors currently include surgical resection, radiation therapy, and chemotherapy. Among these, chemotherapy is one of the most crucial and comprehensive treatment strategies. The rapid progress in nanoscience has fostered the development of nanocarrier compounds and their clinical applications in disease treatment. Notably, nanomedicines, including goserelin sustained-release implants, doxorubicin liposomes, albumin-bound paclitaxel, and paclitaxel liposomes, have been effectively utilized in tumor treatment in China [1]. The article presents a comprehensive overview of recent advancements in utilizing various nanocarriers for combination therapy in tumors. It also examines the clinical application and efficacy of drug delivery carriers. The development of efficient and safe co-delivery systems that facilitate the effective transport and precise release of drugs within the cancerous tissues while also elucidating the internalization of nanoparticles into tumor cells and their functional mechanisms represents critical areas for future research. Concurrently, advancements in nanocarriers and tumor treatment are anticipated to yield superior therapeutic outcomes and improved quality of life for cancer patients.

摘要

恶性肿瘤的高发病率持续对公众健康构成重大威胁。近年来,肿瘤治疗方法取得了显著进展,导致治疗理念和临床方法发生了重大变化。目前治疗恶性肿瘤的主要临床方法包括手术切除、放射治疗和化疗。其中,化疗是最关键和全面的治疗策略之一。纳米科学的迅速发展推动了纳米载体化合物的开发及其在疾病治疗中的临床应用。值得注意的是,包括戈舍瑞林缓释植入剂、阿霉素脂质体、白蛋白结合型紫杉醇和紫杉醇脂质体在内的纳米药物已在中国的肿瘤治疗中得到有效应用[1]。本文全面概述了利用各种纳米载体进行肿瘤联合治疗的最新进展。它还研究了药物递送载体的临床应用和疗效。开发高效、安全的共递送系统,促进药物在癌组织内的有效运输和精确释放,同时阐明纳米颗粒进入肿瘤细胞的内化过程及其功能机制,是未来研究的关键领域。同时,预计纳米载体和肿瘤治疗的进展将为癌症患者带来更好的治疗效果和更高的生活质量。

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Nano and liposome cancer chemotherapy: A review of advances in drug delivery with applications.纳米与脂质体癌症化疗:药物递送进展及其应用综述
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Stealth Nanocarriers in Cancer Therapy: a Comprehensive Review of Design, Functionality, and Clinical Applications.隐形纳米载体在癌症治疗中的应用:设计、功能及临床应用的综合综述。
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