Asin K E, Wirtshafter D
Department of Psychology, University of Illinois, Chicago 60680.
Pharmacol Biochem Behav. 1990 Jun;36(2):417-20. doi: 10.1016/0091-3057(90)90426-i.
The current experiment utilized a modified latent extinction method to examine the question of whether neuroleptic treatment blunts the reinforcing properties of food. Deprived rats were trained to traverse a runway for food reward and were then injected with haloperidol and given ten reinforced direct placements either into the goal box of the alley or into a novel cage with food present. The animals, while still under the influence of the haloperidol, were then given six standard trials of running down the alley. Animals who received goal box placements showed slower run speeds during the test trials than did the subjects who received placements into a neutral cage. These results suggest that placing the haloperidol treated rats into the baited goalbox resulted in a reduced expectation of reward and are compatible with the "anhedonia" theory of neuroleptic action.
当前的实验采用了一种改良的潜在消退方法，以研究抗精神病药物治疗是否会削弱食物的强化特性这一问题。将处于饥饿状态的大鼠训练穿越跑道以获取食物奖励，然后给它们注射氟哌啶醇，并给予十次强化直接放置，要么放入小巷的目标箱中，要么放入有食物的新笼子里。在仍受氟哌啶醇影响的情况下，然后让这些动物进行六次沿着小巷奔跑的标准试验。接受目标箱放置的动物在测试试验中的奔跑速度比接受放置在中性笼子里的受试者要慢。这些结果表明，将接受氟哌啶醇治疗的大鼠放入有诱饵的目标箱中会导致奖励期望降低，这与抗精神病药物作用的“快感缺失”理论相符。
