Feldon J, Katz Y, Weiner I
Department of Psychology, Tel-Aviv University, Israel.
Psychopharmacology (Berl). 1988;95(4):528-33. doi: 10.1007/BF00172968.
The effects of haloperidol 0.1 mg/kg on the partial reinforcement extinction effect (PREE) paradigm at one trial a day, were examined. Two groups of rats were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially reinforced (PRF) group was rewarded on a quasi-random 50% schedule. All animals were then tested in extinction. Haloperidol 0.1 mg/kg was administered in a 2 x 2 design, i.e., drug-no drug in acquisition and drug-no drug in extinction. The PREE, i.e., increased resistance to extinction of partially reinforced as compared to continuously reinforced animals, was obtained in all four drug conditions. The administration of haloperidol in acquisition increased markedly resistance to extinction in CRF animals. The administration of the drug in extinction decreased resistance to extinction in both CRF and PRF animals. The results are explained in terms of two independent actions of haloperidol: the well-known effect of reduction in the effectiveness of reinforcement as well as enhancement of the effectiveness of nonreinforcement.
研究了每天一次试验时，0.1毫克/千克氟哌啶醇对部分强化消退效应（PREE）范式的影响。两组大鼠被训练在直跑道上奔跑。连续强化（CRF）组每次试验都获得食物奖励。部分强化（PRF）组按准随机50%的比例给予奖励。然后对所有动物进行消退测试。以2×2设计给予0.1毫克/千克氟哌啶醇，即在习得阶段给药-不给药以及在消退阶段给药-不给药。在所有四种药物条件下均获得了PREE，即与连续强化动物相比，部分强化动物对消退的抵抗力增强。在习得阶段给予氟哌啶醇显著增加了CRF动物对消退的抵抗力。在消退阶段给予该药物降低了CRF和PRF动物对消退的抵抗力。结果从氟哌啶醇的两个独立作用方面进行了解释：强化效果降低的众所周知的作用以及非强化效果增强的作用。
