Zhang Yiwen, Mu Xinyue, Yu Junpu, Yang Aimin, Yang Jingli, Wu Rongjie, Luo Fanhui, Luo Bin, Chen Rentong, Ma Li, He Jian
School of Public Health, Lanzhou University, Lanzhou, China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region (SAR), China.
Biol Trace Elem Res. 2025 Mar 21. doi: 10.1007/s12011-025-04580-7.
Although environmental exposure to toxic metals and metalloids is linked with the risk of cardiovascular diseases, the evidence is limited in the elderly. We evaluated the associations between 12 plasma metal levels including aluminum (Al), titanium (Ti), strontium (Sr), lead (Pb), vanadium (V), chromium (Cr), cobalt (Co), nickel (Ni), cuprum (Cu), zinc (Zn), arsenic (As), and selenium (Se) with prevalence of hypertension in the elderly Chinese population. In this study, stratified cluster sampling was conducted among elderly residents in three communities in Gansu province from June to July 2023, with a total of 330 participants included. The concentrations of metals in whole plasma were measured using inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression and restricted cubic spline analyses were used to evaluate the dose-response relationship between plasma metal levels and hypertension, with all metal concentrations log-transformed. We applied quantile g-computation (QG-comp) and Bayesian kernel machine regression (BKMR) models to examine the associations of both individual metals and metal mixtures with hypertension. After multivariable adjustments, the odds ratios (ORs) and 95% confidence intervals (CIs) for hypertension associated with the highest quartile of metal concentrations compared to the lowest quartile were as follows: 4.20 (1.36, 12.98) for Sr, 3.95 (1.30, 12.03) for V, 3.43 (1.09, 10.78) for Cr, 3.28 (1.16, 9.28) for Cu, 3.28 (1.13, 9.52) for Zn, and 2.87 (0.94, 8.74) for As. Using BKMR and restricted cubic spline analysis, we found that exposure to metal mixtures was positively associated with an increased risk of hypertension, with Ni, Cr, As, and V being the primary contributing factors. In addition, Zn, Ni, and Sr were significantly and positively correlated with hypertension, while plasma titanium levels were negatively associated with hypertension development. These results suggest a complex interaction between various metals and the risk of hypertension in the elderly. Exposure to metal mixtures was positively associated with hypertension risk in elderly Chinese adults, with Ni, Cr, As, and V as key contributors. In addition, Zn, Ni, and Sr are significantly associated with an increased risk of hypertension, while Ti was positively associated with its development.
尽管环境中接触有毒金属和类金属与心血管疾病风险相关，但在老年人中证据有限。我们评估了包括铝（Al）、钛（Ti）、锶（Sr）、铅（Pb）、钒（V）、铬（Cr）、钴（Co）、镍（Ni）、铜（Cu）、锌（Zn）、砷（As）和硒（Se）在内的12种血浆金属水平与中国老年人群高血压患病率之间的关联。在本研究中，2023年6月至7月在甘肃省三个社区的老年居民中进行分层整群抽样，共纳入330名参与者。使用电感耦合等离子体质谱法（ICP-MS）测量全血中金属的浓度。采用逻辑回归和受限立方样条分析来评估血浆金属水平与高血压之间的剂量反应关系，所有金属浓度均进行对数转换。我们应用分位数g计算（QG-comp）和贝叶斯核机器回归（BKMR）模型来检验个体金属和金属混合物与高血压的关联。多变量调整后，与最低四分位数相比，金属浓度最高四分位数与高血压相关的比值比（OR）和95%置信区间（CI）如下：Sr为4.20（1.36，12.98），V为3.95（1.30，12.03），Cr为3.43（1.09，10.78），Cu为3.28（1.16，9.28），Zn为3.28（1.13，9.52），As为2.87（0.94，8.74）。使用BKMR和受限立方样条分析，我们发现接触金属混合物与高血压风险增加呈正相关，镍、铬、砷和钒是主要促成因素。此外，锌、镍和锶与高血压显著正相关，而血浆钛水平与高血压发展呈负相关。这些结果表明各种金属与老年人高血压风险之间存在复杂的相互作用。在中国老年成年人中，接触金属混合物与高血压风险呈正相关，镍、铬、砷和钒是关键促成因素。此外，锌、镍和锶与高血压风险增加显著相关，而钛与高血压发展呈正相关。
