Jiang Shibo, Wu Fan
Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China.
Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China.
Cell. 2025 Mar 20;188(6):1465-1468. doi: 10.1016/j.cell.2025.02.004.
Three studies published in this issue of Cell reveal that multiple MERS-related coronaviruses (MERSr-CoVs) utilize ACE2, rather than the canonical Merbecovirus receptor DPP4, for cell entry. These ACE2-dependent MERSr-CoVs pose a risk of zoonotic transmission to humans with high transmissibility potential like SARS-CoV-2, thus calling for global surveillance and countermeasures.
本期《细胞》杂志发表的三项研究表明，多种中东呼吸综合征相关冠状病毒（MERSr-CoV）利用血管紧张素转换酶2（ACE2）而非典型的默贝病毒受体二肽基肽酶4（DPP4）进入细胞。这些依赖ACE2的MERSr-CoV具有像严重急性呼吸综合征冠状病毒2（SARS-CoV-2）那样高传播潜力的人畜共患病传播给人类的风险，因此需要全球监测和应对措施。
