对具有外溢风险的利用ACE2的中东呼吸综合征相关冠状病毒的全球监测及应对措施。
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk.
作者信息
Jiang Shibo, Wu Fan
机构信息
Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China.
Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China.
出版信息
Cell. 2025 Mar 20;188(6):1465-1468. doi: 10.1016/j.cell.2025.02.004.
Three studies published in this issue of Cell reveal that multiple MERS-related coronaviruses (MERSr-CoVs) utilize ACE2, rather than the canonical Merbecovirus receptor DPP4, for cell entry. These ACE2-dependent MERSr-CoVs pose a risk of zoonotic transmission to humans with high transmissibility potential like SARS-CoV-2, thus calling for global surveillance and countermeasures.
本期《细胞》杂志发表的三项研究表明，多种中东呼吸综合征相关冠状病毒（MERSr-CoV）利用血管紧张素转换酶2（ACE2）而非典型的默贝病毒受体二肽基肽酶4（DPP4）进入细胞。这些依赖ACE2的MERSr-CoV具有像严重急性呼吸综合征冠状病毒2（SARS-CoV-2）那样高传播潜力的人畜共患病传播给人类的风险，因此需要全球监测和应对措施。
Zotero 插件