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Predicted early fusion intermediates in the spike of ACE2-utilising bat coronavirus unveil broad-spectrum antiviral mechanisms.

作者信息

Sun Lujia, Liu Zhimin, Xing Lixiao, Liang Xiaoxing, Lu Lu, Jiang Shibo, Sun Lei, Wang Xinling

机构信息

Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Institute of Biomedical Sciences, Fudan University, Shanghai, China.

Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.

出版信息

Clin Transl Med. 2025 Sep;15(9):e70459. doi: 10.1002/ctm2.70459.

DOI:10.1002/ctm2.70459
PMID:40916689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12415440/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0992/12415440/85841e41d313/CTM2-15-e70459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0992/12415440/626971f1e58c/CTM2-15-e70459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0992/12415440/85841e41d313/CTM2-15-e70459-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0992/12415440/626971f1e58c/CTM2-15-e70459-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0992/12415440/85841e41d313/CTM2-15-e70459-g002.jpg

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本文引用的文献

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Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk.对具有外溢风险的利用ACE2的中东呼吸综合征相关冠状病毒的全球监测及应对措施。
Cell. 2025 Mar 20;188(6):1465-1468. doi: 10.1016/j.cell.2025.02.004.
2
Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor.感染蝙蝠的梅伯科病毒HKU5-CoV谱系2可利用人类血管紧张素转换酶2作为细胞进入受体。
Cell. 2025 Mar 20;188(6):1729-1742.e16. doi: 10.1016/j.cell.2025.01.042. Epub 2025 Feb 18.
3
Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses.
香港大学5型冠状病毒中血管紧张素转换酶2(ACE2)受体利用趋同进化的分子基础
Cell. 2025 Mar 20;188(6):1711-1728.e21. doi: 10.1016/j.cell.2024.12.032. Epub 2025 Feb 7.
4
Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses.中东呼吸综合征相关冠状病毒中ACE2使用的多次独立获得
Cell. 2025 Mar 20;188(6):1693-1710.e18. doi: 10.1016/j.cell.2024.12.031. Epub 2025 Feb 7.
5
Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target.利用血管紧张素转换酶2的冠状病毒刺突蛋白早期融合中间体作为抗病毒靶点。
Cell. 2025 Mar 6;188(5):1297-1314.e24. doi: 10.1016/j.cell.2025.01.012. Epub 2025 Jan 30.
6
Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane.SARS-CoV-2 融合后刺突在膜中的冷冻电镜结构。
Nature. 2023 Jul;619(7969):403-409. doi: 10.1038/s41586-023-06273-4. Epub 2023 Jun 7.
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Close relatives of MERS-CoV in bats use ACE2 as their functional receptors.蝙蝠中东呼吸综合征冠状病毒的近亲利用 ACE2 作为其功能性受体。
Nature. 2022 Dec;612(7941):748-757. doi: 10.1038/s41586-022-05513-3. Epub 2022 Dec 7.
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