Kornblum David S, Rosero Basurto Maria F, Chima Ranjit S, Greene John N
Infectious Disease, University of South Florida, Clearwater, Florida, USA.
Hospital Medicine, Memorial West Hospital, Pembroke Pines, Florida, USA.
JACC Case Rep. 2025 Mar 19;30(6 Pt 1):103199. doi: 10.1016/j.jaccas.2024.103199.
Infectious aortitis is a rare, life-threatening condition, with Escherichia coli being an exceptionally uncommon causative pathogen. This case series highlights 2 instances of E coli-induced aortitis in immunocompromised patients, illustrating the clinical challenges and management approaches. The first case involves a 54-year-old man with Waldenstrom macroglobulinemia and recurrent diverticulitis, requiring intravenous antibiotics and endovascular aneurysm repair. The second case features a 66-year-old man with acute myeloid leukemia, successfully managed with antimicrobial therapy alone. These cases underscore the need for early recognition, appropriate imaging, and a multidisciplinary approach for optimal outcomes in E coli-induced infectious aortitis.
感染性主动脉炎是一种罕见的、危及生命的疾病，大肠杆菌是极为罕见的致病病原体。本病例系列突出了免疫功能低下患者中2例大肠杆菌所致主动脉炎的情况，阐明了临床挑战及处理方法。首例病例为一名54岁患有华氏巨球蛋白血症和复发性憩室炎的男性，需要静脉使用抗生素及进行血管内动脉瘤修复。第二例病例是一名66岁患有急性髓细胞白血病的男性，仅通过抗菌治疗即成功治愈。这些病例强调了对于大肠杆菌所致感染性主动脉炎，为实现最佳治疗效果而进行早期识别、恰当影像学检查及多学科方法的必要性。
