Dagi Glass Lora R, Aakalu Vinay K, Foster Jill A, Grob Seanna R, McCulley Timothy J, Tao Jeremiah, Vagefi M Reza, Yoon Michael, Pineles Stacy L, Wladis Edward J
Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York.
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.
Ophthalmology. 2025 Jul;132(7):842-847. doi: 10.1016/j.ophtha.2025.01.019. Epub 2025 Mar 22.
To review the literature for protocols and results of patch testing for allergic contact dermatitis (ACD) in patients with noninfectious eyelid dermatitis.
A literature search of the PubMed database was conducted last in July 2024. Articles were limited to original research for which an English language abstract was available, and in which detailed data were available for at least 25 patients being tested for noninfectious eyelid dermatitis. Of the 135 articles identified, 17 studies were reviewed in full text and were selected for inclusion and grading. All studies were rated level III.
Multiple allergens may cause ACD. The following allergens with at least 10% positivity were reported in more than 1 study (although the same allergens were not examined in every study): Balsam of Peru (Myroxylon pereirae), cinnamic alcohol, fragrance mixes, gold, methylisothiazolinone, nail care products, neomycin, nickel, and personal care products (broadly defined as any product used by a patient at home).
An ideal patch test panel for eyelid ACD remains to be determined; patients with suspected eyelid ACD benefit from a depth and breadth of patch testing beyond common allergens such as Balsam of Peru, cinnamic alcohol, fragrance mixes, gold, methylisothiazolinone, nail care products, neomycin, and nickel. Future research would benefit from a prospective methodology, greater demographic detail, and postpatching follow-up.
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
回顾关于非感染性眼睑皮炎患者过敏性接触性皮炎（ACD）斑贴试验方案及结果的文献。
2024年7月最后一次对PubMed数据库进行文献检索。文章限于有英文摘要的原创研究，且有至少25例接受非感染性眼睑皮炎检测患者的详细数据。在检索到的135篇文章中，对17项研究进行了全文审查，并选择纳入和分级。所有研究均评为III级。
多种变应原可引起ACD。在不止1项研究中报告了以下阳性率至少为10%的变应原（尽管并非每项研究都检测相同的变应原）：秘鲁香脂（秘鲁胶木）、肉桂醇、香料混合物、金、甲基异噻唑啉酮、美甲护理产品、新霉素、镍和个人护理产品（广义定义为患者在家中使用的任何产品）。
用于眼睑ACD的理想斑贴试验组合仍有待确定；疑似眼睑ACD的患者从超出秘鲁香脂、肉桂醇、香料混合物、金、甲基异噻唑啉酮、美甲护理产品、新霉素和镍等常见变应原的深度和广度的斑贴试验中获益。未来的研究将受益于前瞻性方法、更详细的人口统计学信息和斑贴试验后的随访。
作者对本文讨论的任何材料均无所有权或商业利益。
