Sioutas Georgios, Gelasakis Athanasios I, Beugnet Frederic, Papadopoulos Elias
Laboratory of Parasitology and Parasitic Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Laboratory of Anatomy and Physiology of Farm Animals, Department of Animal Science, School of Animal Biosciences, Agricultural University of Athens, 11855 Athens, Greece.
Vet Parasitol Reg Stud Reports. 2025 Apr;59:101228. doi: 10.1016/j.vprsr.2025.101228. Epub 2025 Feb 18.
Notoedres cati is a contagious, burrowing mite infesting cats that causes mange with intense pruritus and dermatological clinical signs. The aim of the current study was to assess the efficacy of a single administration of NexGard® Combo (esafoxolaner, eprinomectin and praziquantel) against N. cati in naturally infested cats under home conditions. A total of 17 domestic shorthair cats naturally infested with N. cati that were living in the same house were randomly assigned to either the treatment group (n = 9) receiving NexGard® Combo at a dosage of 0.12 mL/kg of their body weight according to label instructions or a negative control group (n = 8) receiving mineral oil at 0.12 mL/kg (Day 0). The cats were separated into different rooms with no contact between the two groups in the same household. Clinical scores, mite counts from skin scrapings and body weights were evaluated on Days -3, 0, 14, 28, 42, and 56. Descriptive statistics (means ± standard deviations) were calculated, and a mixed general linear model was used for statistical analysis. NexGard® Combo showed 100 % efficacy against N. cati, and no live mites were found from Day 14 until the end of the study. Treated cats also exhibited lower clinical scores and higher body weights than the control group by Day 56 (p < 0.05), while placebo-treated cats displayed high mite counts and clinical scores throughout the study. None of the cats displayed any adverse events related to treatment. These findings highlight the efficacy of the combination of esafoxolaner, eprinomectin and praziquantel in treating notoedric mange in cats under in-home conditions.
猫背肛螨是一种具有传染性的掘穴螨，寄生于猫身上，可引起剧烈瘙痒的疥螨病及皮肤临床症状。本研究的目的是评估在家养条件下，单次给予NexGard® Combo（依沙氟拉钠、埃普利诺菌素和吡喹酮）对自然感染猫背肛螨的猫的疗效。共有17只生活在同一房屋内自然感染猫背肛螨的家养短毛猫，被随机分为治疗组（n = 9），按照标签说明以0.12 mL/kg体重的剂量给予NexGard® Combo，或阴性对照组（n = 8），给予0.12 mL/kg的矿物油（第0天）。将猫分置于不同房间，同一家庭中的两组之间无接触。在第-3、0、14、28、42和56天评估临床评分、皮肤刮片中的螨计数和体重。计算描述性统计量（均值±标准差），并使用混合广义线性模型进行统计分析。NexGard® Combo对猫背肛螨显示出100%的疗效，从第14天到研究结束均未发现活螨。到第56天，治疗组猫的临床评分也低于对照组，体重高于对照组（p < 0.05），而接受安慰剂治疗的猫在整个研究过程中螨计数和临床评分都很高。没有猫表现出与治疗相关的任何不良事件。这些发现突出了依沙氟拉钠、埃普利诺菌素和吡喹酮联合用药在家养条件下治疗猫背肛螨疥螨病的疗效。
