Hong S K, Pendergast D R, Krasney J A, Claybaugh J R
J UOEH. 1985 Mar 1;7 Suppl:205-14.
HOI induces a significant increase in the cardiac output, which is accompanied by increases in the urinary excretion of water, Na and K. However, the renal responses are not always associated with the cardiac response, suggesting a possible dissociation of two events. Although the urinary excretion of both ADH and aldosterone decreases during HOI, the mechanism for these changes is not clearly understood. The renal responses to HOI, especially the natriuresis, is considerably attenuated in endurance-trained athletes, which may be related to the more moderate inhibition of both ADH and renin-aldosterone systems. The exact role of the cardiac receptors in inducing the renal responses to HOI is still not defined, although the latter receptors are involved in inducing the natriuresis. Finally, important diurnal variations have been demonstrated for the renal responses to HOI, and elucidation of the mechanism for this interesting phenomenon may help understand the overall mechanisms for the development of cardiorenal-endocrine responses to HOI.
热浸入诱导心输出量显著增加，同时伴有水、钠和钾尿排泄量增加。然而，肾脏反应并不总是与心脏反应相关，这表明这两个事件可能存在分离。尽管在热浸入期间抗利尿激素（ADH）和醛固酮的尿排泄量均减少，但这些变化的机制尚不清楚。耐力训练的运动员对热浸入的肾脏反应，尤其是利钠作用，会显著减弱，这可能与ADH和肾素-醛固酮系统受到更适度的抑制有关。尽管后者的受体参与诱导利钠作用，但心脏受体在诱导肾脏对热浸入反应中的具体作用仍未明确。最后，已经证明肾脏对热浸入的反应存在重要的昼夜变化，阐明这一有趣现象的机制可能有助于理解心脏-肾脏-内分泌对热浸入反应的总体机制。
