Zhao Zepeng, Li Yijin, Zhang Fengyuan, Gao Lixia, Lin Haiyan
Savaid Stomatology School, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Savaid Stomatology School, Hangzhou Medical College, Hangzhou, Zhejiang, China; Hangzhou Stomatological Hospital, Hangzhou, Zhejiang, China.
J Craniomaxillofac Surg. 2025 Jul;53(7):960-969. doi: 10.1016/j.jcms.2025.03.009. Epub 2025 Mar 22.
A maxillary sinus lift is a dental surgery that increases bone volume to allow for dental implant insertion. Platelet concentrate (PC) has been proposed as an adjunct to maxillary sinus lift surgery to enhance bone regeneration. The efficacy of PC this surgery is evaluated in this meta-analysis.
We looked for research on PCs used in maxillary sinus lift operations in online databases. Two separate reviewers assessed the possibility of bias after extracting the data. A meta-analysis evaluated the differences in bone regeneration outcomes between PC + graft group and graft only group.
The review incorporated a total of 19 RCTs. The results of the meta-analysis demonstrated that the use of PC in maxillary sinus lift procedures significantly facilitated the utilisation and resorption of graft material (MD = -3.05; 95% CI: -4.91, -1.18; p = 0.02), improved new bone height (MD = 0.99; 95% CI: 0.21, 1.77; p = 0.01), and new bone formation/bone formation rate (BFR) (MD = 4.76; 95% CI: 0.98, 8.54; p = 0.01), compared to control groups. However, we found no significant difference in terms of soft tissue formation, implant stability quotient, implant success rate, complication rate, and contact between new and existing bone.
This meta-analysis demonstrates that the application of PC as an adjunct to maxillary sinus lift surgery can improve bone regeneration outcomes while not elevating the risk of complications. Further research is necessary to confirm the results and to determine the most effective protocol for the application of PC in clinical settings.
上颌窦提升术是一种增加骨量以允许植入牙种植体的牙科手术。血小板浓缩物（PC）已被提议作为上颌窦提升术的辅助手段以促进骨再生。本荟萃分析评估了PC在该手术中的疗效。
我们在在线数据库中查找有关上颌窦提升手术中使用PC的研究。两名独立的审阅者在提取数据后评估了偏倚的可能性。荟萃分析评估了PC+移植物组和仅移植物组之间骨再生结果的差异。
该综述共纳入19项随机对照试验。荟萃分析结果表明，在上颌窦提升手术中使用PC显著促进了移植物材料的利用和吸收（MD=-3.05；95%CI：-4.91，-1.18；p=0.02），改善了新骨高度（MD=0.99；95%CI：0.21，1.77；p=0.01）以及新骨形成/骨形成率（BFR）（MD=4.76；95%CI：0.98，8.54；p=0.01），与对照组相比。然而，我们发现在软组织形成、种植体稳定性商数、种植体成功率、并发症发生率以及新骨与现有骨之间的接触方面没有显著差异。
本荟萃分析表明，将PC作为上颌窦提升手术的辅助手段可以改善骨再生结果，同时不增加并发症风险。需要进一步研究以证实结果并确定PC在临床环境中应用的最有效方案。
