Guo De-Xin, Guo Xiao-Wei, Yang Guang-Hui, Sun Yi-Bao, Song Ya, Wang Jin-Lu, Jiang Wei-Bo, Yu Tong
Department of Spinal Surgery, Zhengzhou Orthopaedics Hospital, Zhengzhou, Henan Province, China.
Department of Spinal Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Sci Rep. 2025 Mar 22;15(1):9892. doi: 10.1038/s41598-025-91923-y.
To evaluate the therapeutic efficacy of bone-disc-bone osteotomy (BDBO) via a posterior approach in combination with biomimetic bone grafting and pedicle screw implantation for the treatment of Kümmell disease complicated with kyphosis. Between March 2012 and June 2020, we retrospectively analyzed 22 patients who had Kümmell disease complicated with kyphosis and underwent BDBO in combination with biomimetic bone grafting and pedicle screw implantation. The kyphotic Cobb angle, visual analog scale (VAS), Oswestry Disability Index (ODI), and American Spinal Injury Association (ASIA) Impairment Scale were used to evaluate the effects of surgery. In addition, surgical conditions, including duration of surgery, intraoperative blood loss, and surgical complications, were recorded. The mean follow-up time was 32.86 months (range, 28.27 to 36.67). The mean operative time was 176.68 ± 25.96 min and the mean intraoperative blood loss was 281.24 ± 43.26 mL. The VAS, ODI, and kyphotic Cobb angles were significantly improved 1 week after surgery compared with preoperative assessments and remained well maintained at final follow-up. Eight patients (36.4%) had mild neurologic impairment before surgery, and their neurologic function normalized at final follow-up. The rate of intervertebral fusion at the final follow-up was 100%. One patient (4.5%) had an infected incision that healed after debridement. There was no case of instrumentation failure. BDBO in combination with biomimetic bone grafting and pedicle screw implantation is a novel, safe, effective and elective treatment strategy for patients who experienced Kümmell disease complicated by kyphosis.
评估后路骨-椎间盘-骨截骨术(BDBO)联合仿生骨移植和椎弓根螺钉植入治疗合并后凸畸形的Kümmell病的疗效。2012年3月至2020年6月,我们回顾性分析了22例合并后凸畸形的Kümmell病患者,他们接受了BDBO联合仿生骨移植和椎弓根螺钉植入治疗。采用后凸Cobb角、视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)和美国脊髓损伤协会(ASIA)损伤分级来评估手术效果。此外,记录手术情况,包括手术时间、术中出血量和手术并发症。平均随访时间为32.86个月(范围28.27至36.67个月)。平均手术时间为176.68±25.96分钟,平均术中出血量为281.24±43.26毫升。与术前评估相比,术后1周VAS、ODI和后凸Cobb角均有显著改善,并在末次随访时保持良好。8例患者(36.4%)术前有轻度神经功能障碍,末次随访时神经功能恢复正常。末次随访时椎间融合率为100%。1例患者(4.5%)切口感染,清创后愈合。无内固定失败病例。BDBO联合仿生骨移植和椎弓根螺钉植入是治疗合并后凸畸形Kümmell病患者的一种新颖、安全、有效且可选择的治疗策略。