Attia Yasmin M, Tadros Samer A, Fahim Sally A, Badr Doaa M
Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr Al Eini Street, Fom El Khalig, Cairo, 11796, Egypt.
Department of Biochemistry, Faculty of Pharmacy, 110123october University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
J Egypt Natl Canc Inst. 2025 Mar 24;37(1):9. doi: 10.1186/s43046-025-00266-2.
Accumulated evidence supported the crucial role of a tiny population of cells within the tumor called cancer stem cells (CSCs) in cancer origination, and proliferation. Additionally, these cells are distinguished by their self-renewal, differentiation, and therapeutic resistance capabilities. Interestingly, many studies recorded dysregulation of different types of noncoding RNAs, such as microRNA (miRNA) and long non-coding RNA (LncRNA), in cancer cells as well as CSCs. Moreover, several studies also supported the regulation of the transcription factors and signaling pathways required for CSC progression by these noncoding RNAs. However, the exact biological functions of all these noncoding RNAs are not well understood yet. These findings are of great interest, implying usage of noncoding RNA as therapeutic tool to target these cells. In this review, we provide an insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully.
越来越多的证据支持肿瘤内一小部分被称为癌症干细胞（CSCs）的细胞在癌症发生和增殖中起关键作用。此外，这些细胞具有自我更新、分化和抗治疗能力。有趣的是，许多研究记录了癌细胞以及癌症干细胞中不同类型非编码RNA的失调，如微小RNA（miRNA）和长链非编码RNA（LncRNA）。此外，一些研究还支持这些非编码RNA对癌症干细胞进展所需的转录因子和信号通路的调控。然而，所有这些非编码RNA的确切生物学功能尚未完全了解。这些发现引起了极大的兴趣，意味着可将非编码RNA用作靶向这些细胞的治疗工具。在这篇综述中，我们深入探讨了非编码RNA如何调控癌症干细胞，以及如何利用这种相关性开发新的疗法以成功根除癌细胞。
