标准：人肝芯片。
Standard: human liver-on-a-chip.
作者信息
Liu Haitao, Zhang Xu, Wang Yaqing, Zhang Min, Wang Peng, Shang Jing, Li Zhongqiang, Gong Likun, Xie Xin, Liu Dongyang, Pi Jingbo, Gao Xinghua, Li Xianliang, Ding Wei, Wang Dianbing, Long Yun, Wang Lan, Li Song, Geng Xingchao, Zhou Pingkun, Tang Wanjin, Zhang Xian'en, Chen Chunying, Yang Shengli, Qin Jianhua
机构信息
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
University of Science and Technology of China, Hefei, China.
出版信息
Cell Regen. 2025 Mar 24;14(1):9. doi: 10.1186/s13619-025-00226-0.
Organs-on-chips are microphysiological systems designed to replicate key functions of human organs, thereby accelerating innovation in life sciences, such as disease modeling, drug development, and precision medicine. However, the lack of standardized definitions, structural designs, cell sources, model constructions, and functional validations has posed challenges to their widespread translational applications. On April 29, 2024, the Chinese Society of Biotechnology introduced "Organs-on-chips: Liver", China's first group standard for human liver-on-a-chip technology. This pioneering standard provides comprehensive guidelines, including scope, terminology, definitions, technical requirements, detection methods, and quality control measures for developing liver models on chips. The introduction of this standard is set to facilitate the establishment of institutional protocols, promote widespread adoption, and drive the international standardization of liver-on-a-chip technologies.
器官芯片是旨在复制人体器官关键功能的微生理系统，从而加速生命科学领域的创新，如疾病建模、药物开发和精准医学。然而，缺乏标准化的定义、结构设计、细胞来源、模型构建和功能验证对其广泛的转化应用构成了挑战。2024年4月29日，中国生物技术协会推出了《器官芯片：肝脏》，这是中国首个关于人肝脏芯片技术的团体标准。这项开创性的标准提供了全面的指南，包括用于在芯片上开发肝脏模型的范围、术语、定义、技术要求、检测方法和质量控制措施。该标准的推出将有助于建立机构协议，促进广泛采用，并推动肝脏芯片技术的国际标准化。
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