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磁肿瘤学:自由基对入门

Magneto-oncology: a radical pair primer.

作者信息

Hore P J

机构信息

Department of Chemistry, Oxford University, Oxford, United Kingdom.

出版信息

Front Oncol. 2025 Mar 7;15:1539718. doi: 10.3389/fonc.2025.1539718. eCollection 2025.

Abstract

There are few well-established biophysical mechanisms by which external magnetic fields can influence the biochemistry of molecules in living systems. The radical pair mechanism is arguably the most promising. In this mini-review I summarize the characteristics of radical pairs in a way that may be useful to those engaged in the field of magneto-oncology. The intention is to help researchers decide whether an observed biomedical magnetic field effect could have its origin in radical pair biochemistry. Armed with a physically plausible interaction mechanism, it may be possible to devise and refine a theoretical model and thereby iteratively optimise therapeutic protocols. Such an approach may also help identify experimental artefacts.

摘要

外部磁场能够影响生命系统中分子生物化学的成熟生物物理机制寥寥无几。自由基对机制可以说是最具前景的。在这篇小型综述中,我以一种可能对磁肿瘤学领域的研究人员有用的方式总结了自由基对的特征。目的是帮助研究人员判断观察到的生物医学磁场效应是否可能源于自由基对生物化学。有了一个物理上合理的相互作用机制,就有可能设计和完善理论模型,从而迭代优化治疗方案。这种方法也可能有助于识别实验假象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cad/11925880/fccd2e0d7d31/fonc-15-1539718-g001.jpg

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