Nouri Ahmad, Awashra Ameer, Alnees Mohammad, Rabee Hadi, Shamlawi Alaa
Department of Medicine, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine.
Harvard Medical School Postgraduate Medical Education, Global Clinical Scholars Research Training program, Boston, United States.
Oxf Med Case Reports. 2025 Mar 20;2025(3):omae208. doi: 10.1093/omcr/omae208. eCollection 2025 Mar.
Catastrophic Antiphospholipid Syndrome (CAPS), an autoimmune disease that causes multi-organ thromboses leading to their failure, is a rapidly developing form of antiphospholipid syndrome (APS). APS may be a primary disease or secondary to an autoimmune condition like Systemic Lupus Erythematosus (SLE). A 31-year-old male patient with unremarkable medical history presented with a sudden onset of left-sided body weakness including upper and lower extremities, frontal headache, and slurred speech. Diagnostic workup revealed diffuse ST elevation with elevated cardiac enzymes, elevated inflammatory markers, prolonged activated partial thromboplastin time (aPTT), hemolytic anemia, and intrarenal kidney injury. Further investigations confirmed the diagnosis of probable CAPS secondary to SLE, based on the simultaneous involvement of the brain, heart, and kidneys, along with the presence of positive antiphospholipid antibodies (aPL). The patient showed significant improvement in neurological functioning after treatment with Methylprednisolone, Hydroxychloroquine, Colchicine, and Rituximab.
灾难性抗磷脂综合征（CAPS）是抗磷脂综合征（APS）的一种快速发展形式，是一种自身免疫性疾病，可导致多器官血栓形成并进而导致器官功能衰竭。APS 可能是原发性疾病，也可能继发于自身免疫性疾病，如系统性红斑狼疮（SLE）。一名 31 岁男性患者，既往病史无异常，突然出现左侧肢体无力，包括上肢和下肢，伴有额部头痛和言语不清。诊断检查显示弥漫性 ST 段抬高，心肌酶升高，炎症标志物升高，活化部分凝血活酶时间（aPTT）延长，溶血性贫血和肾内肾损伤。进一步检查基于脑、心脏和肾脏同时受累以及抗磷脂抗体（aPL）阳性，确诊为可能继发于 SLE 的 CAPS。患者在接受甲基强的松龙、羟氯喹、秋水仙碱和利妥昔单抗治疗后神经功能有显著改善。
