Mathur Mahesh, Thakur Neha, Regmi Sandhya, Paudel Supriya, Bhattarai Nabita, Karki Sambidha
Department of Dermatology, College of Medical Sciences Teaching Hospital, Bharatpur, Nepal.
Skin Health Dis. 2025 Jan 22;5(1):50-52. doi: 10.1093/skinhd/vzae006. eCollection 2025 Feb.
Fixed drug eruption (FDE) is a distinct adverse drug reaction characterized by a well-defined, dusky, violaceous to erythematous patch that recurs at the same site upon re-exposure to causative drugs and resolves with hyperpigmentation. This unique reaction is a type IV hypersensitivity reaction mediated by memory CD8 T cells that reside in the basal layer of the epidermis of the resting FDE lesion. Variants of FDE described in the literature include bullous, generalized bullous, nonpigmenting, linear, papular, erythema multiforme-like, transitory giant, annular, psoriasiform, erythema dyschromicum perstans-like and cellulitis-like. We present the case of a 12-year-old boy with FDE in a cribriform pattern that has not been defined so far.
固定性药疹（FDE）是一种独特的药物不良反应，其特征为界限清晰、色泽暗沉、呈紫蓝色至红斑样的斑片，再次接触致病药物时会在同一部位复发，并伴有色素沉着而消退。这种独特的反应是一种IV型超敏反应，由驻留在静止FDE皮损表皮基底层的记忆性CD8 T细胞介导。文献中描述的FDE变体包括大疱性、泛发性大疱性、无色素沉着性、线状、丘疹性、多形红斑样、暂时性巨疹性、环状、银屑病样、持久性色素异常性红斑样和蜂窝织炎样。我们报告了一例12岁男孩出现筛状模式的FDE病例，该模式迄今尚未有过定义。
