S Dr Sanidhya, Kamath Deepa, Sinha Aradhya, Kamath Diya
Department of Periodontology, Manipal Academy of Higher Education, Manipal, Karnataka, 575001, India.
BDS, Manipal college of dental science, Manipal, India.
F1000Res. 2025 Jan 14;14:77. doi: 10.12688/f1000research.159942.1. eCollection 2025.
Melatonin, the "sleep hormone," shows significant promise in dentistry owing to its antioxidant, anti-inflammatory, and immunomodulatory properties. It is beneficial for treating periodontal disorders and aiding osseointegration of dental implants. Additionally, melatonin helps to manage dental anxiety, offering an alternative to traditional sedatives. Periodontal disease is orchestrated by bacterial plaques along with an exaggerated immune-inflammatory host response. Treatment of periodontitis not only involves the removal of plaque, but also aims to minimize the cytokine load and control the reactive oxygen species burden in the tissues, which would re-establish a healthy periodontium and a balanced bone metabolism. Melatonin is known to exert beneficial effects, such as regulation of circadian rhythm, bone remodeling, and antimicrobial effects. Recent studies have demonstrated the successful use of melatonin as an adjunct to mechanical debridement for the treatment of periodontal disease. Its various uses include systemic administration of melatonin after one-stage full-mouth Non-Surgical Periodontal Therapy in healthy subjects as well as patients. This article provides a summary of the various clinical applications of melatonin, describing its mechanism of action, uses, and potential avenues for future research in dentistry.
褪黑素，即“睡眠激素”，因其抗氧化、抗炎和免疫调节特性，在牙科领域展现出显著前景。它对治疗牙周疾病和促进牙种植体的骨整合有益。此外，褪黑素有助于应对牙科焦虑，为传统镇静剂提供了一种替代选择。牙周病是由细菌菌斑以及过度的免疫炎症宿主反应共同引发的。牙周炎的治疗不仅包括清除菌斑，还旨在使细胞因子负荷最小化，并控制组织中的活性氧负担，从而重建健康的牙周组织和平衡的骨代谢。众所周知，褪黑素具有多种有益作用，如调节昼夜节律、骨重塑和抗菌作用。最近的研究表明，褪黑素作为机械清创治疗牙周病的辅助手段已取得成功。其各种用途包括在健康受试者以及患者接受一期全口非手术牙周治疗后进行褪黑素的全身给药。本文总结了褪黑素的各种临床应用，描述了其作用机制、用途以及牙科未来研究的潜在途径。
