Das Subhadeep, Basak Sampad, Sarkar Soumyadev
Department of Biochemistry, Purdue University, BCHM A343, 175 S. University Street, West Lafayette, IN 47907-2063, USA.
Purdue University Institute for Cancer Research, Purdue University, Hansen Life Sciences Research Building, Room 141, 201 S. University Street, West Lafayette, IN 47907-2064, USA.
Noncoding RNA. 2025 Mar 20;11(2):28. doi: 10.3390/ncrna11020028.
Oral cancer (OC) ranks among the most prevalent head and neck cancers, becoming the eleventh most common cancer worldwide with ~350,000 new cases and 177,000 fatalities annually. The rising trend in the occurrence of OC among young individuals and women who do not have tobacco habits is escalating rapidly. Surgical procedures, radiation therapy, and chemotherapy are among the most prevalent treatment options for oral cancer. To achieve better therapy and an early detection of the cancer, it is essential to understand the disease's etiology at the molecular level. Saliva, the most prevalent body fluid obtained non-invasively, holds a collection of distinct non-coding RNA pools (ncRNAomes) that can be assessed as biomarkers for identifying oral cancer. Non-coding signatures, which are transcripts lacking a protein-coding function, have been identified as significant in the progression of various cancers, including oral cancer. This review aims to examine the role of various salivary ncRNAs (microRNA, circular RNA, and lncRNA) associated with disease progression and to explore their functions as potential biomarkers for early disease identification to ensure better survival outcomes for oral cancer patients.
口腔癌（OC）是最常见的头颈癌之一，成为全球第十一大常见癌症，每年约有35万新发病例和17.7万例死亡。在无吸烟习惯的年轻人和女性中，OC发病率的上升趋势正在迅速加剧。手术、放疗和化疗是口腔癌最常见的治疗选择。为了实现更好的治疗和癌症的早期检测，在分子水平上了解该疾病的病因至关重要。唾液是最容易通过非侵入性获得的体液，含有一系列独特的非编码RNA库（ncRNAome），可作为识别口腔癌的生物标志物进行评估。非编码特征是缺乏蛋白质编码功能的转录本，已被确定在包括口腔癌在内的各种癌症进展中具有重要意义。本综述旨在研究各种唾液ncRNA（微小RNA、环状RNA和长链非编码RNA）与疾病进展相关的作用，并探索它们作为早期疾病识别潜在生物标志物的功能，以确保口腔癌患者有更好的生存结果。
