School of Stomatology and Ophthalmology, Xianning Medical College, Hubei University of Science and Technology, Xianning Hubei, China.
School of Clinical Medicine, Xianning Medical College, Hubei University of Science and Technology, Xianning Hubei, China.
J Cancer Res Ther. 2024 Aug 1;20(4):1141-1149. doi: 10.4103/jcrt.jcrt_44_24. Epub 2024 Aug 29.
As the initial point for digestion, the balance of oral microorganisms plays an important role in maintaining local and systemic health. Oral dysbiosis, or an imbalance in the oral microbial community, may lead to the onset of various diseases. The presence or abnormal increase of microbes in the oral cavity has attracted significant attention due to its complicated relationship with oral cancer. Oral cancer can remodel microbial profiles by creating a more beneficial microenvironment for its progression. On the other hand, altered microbial profiles can promote tumorigenesis by evoking a complex inflammatory response and affecting host immunity. This review analyzes the oncogenic potential of oral microbiome alterations as a driver and biomarker. Additionally, a potentially therapeutic strategy via the reversal of the oral microbiome dysbiosis in oral cancers has been discussed.
作为消化的初始点，口腔微生物的平衡对维持局部和全身健康起着重要作用。口腔微生态失调或口腔微生物群落失衡，可能导致各种疾病的发生。由于口腔微生物与口腔癌之间的复杂关系，口腔中微生物的存在或异常增加引起了人们的极大关注。口腔癌可以通过为其进展创造更有利的微环境来重塑微生物谱。另一方面，改变的微生物谱可以通过引发复杂的炎症反应和影响宿主免疫来促进肿瘤发生。本综述分析了口腔微生物组改变作为驱动因素和生物标志物的致癌潜力。此外，还讨论了通过逆转口腔癌中的口腔微生物失调来实现潜在治疗策略的可能性。
