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Should Liberal Fluid Therapy (Compared to Restrictive Fluid Therapy) be Used in Children with Septic Shock? Yes.

作者信息

Nallasamy Karthi, Venkateshwaralu Saicharan

机构信息

Pediatric Critical Care Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

出版信息

Indian Pediatr. 2025 Mar;62(3):233-235. doi: 10.1007/s13312-025-00013-9.

DOI:10.1007/s13312-025-00013-9
PMID:40126832
Abstract
摘要

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Should Liberal Fluid Therapy (Compared to Restrictive Fluid Therapy) be Used in Children with Septic Shock? Yes.对于感染性休克患儿,是否应采用宽松液体疗法(与限制性液体疗法相比)?答案是肯定的。
Indian Pediatr. 2025 Mar;62(3):233-235. doi: 10.1007/s13312-025-00013-9.
2
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Cochrane Database Syst Rev. 2018 Dec 10;12(12):CD010593. doi: 10.1002/14651858.CD010593.pub2.
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Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.自由与限制静脉输液治疗早期感染性休克:随机试验的理由。
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Cureus. 2023 Oct 27;15(10):e47783. doi: 10.7759/cureus.47783. eCollection 2023 Oct.
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Am J Transl Res. 2025 Mar 15;17(3):2311-2321. doi: 10.62347/PGBB6148. eCollection 2025.
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Should Liberal Fluid Therapy (Compared to Restrictive Fluid Therapy) be used in Children with Septic Shock? No.对于感染性休克患儿,是否应采用宽松液体疗法(与限制性液体疗法相比)?不应该。
Indian Pediatr. 2025 Mar;62(3):229-231. doi: 10.1007/s13312-025-00014-8.
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Restrictive calcium replacement in septic shock: a multicenter before-after intervention study.脓毒性休克时限制钙补充:一项多中心前后干预研究。
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本文引用的文献

1
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.脓毒症性低血压的早期限制或宽松液体管理。
N Engl J Med. 2023 Feb 9;388(6):499-510. doi: 10.1056/NEJMoa2212663. Epub 2023 Jan 21.
2
Point-of-care ultrasonography to predict fluid responsiveness in children: A systematic review and meta-analysis.即时超声检查预测儿童液体反应性:一项系统评价和荟萃分析。
Paediatr Anaesth. 2023 Jan;33(1):24-37. doi: 10.1111/pan.14574. Epub 2022 Oct 19.
3
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
《拯救脓毒症运动:儿童脓毒性休克及脓毒症相关器官功能障碍管理国际指南》
Pediatr Crit Care Med. 2020 Feb;21(2):e52-e106. doi: 10.1097/PCC.0000000000002198.
4
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.严重脓毒症和脓毒性休克的早期目标导向治疗:与ProCESS、ProMISe和ARISE研究的见解及比较
Crit Care. 2016 Jul 1;20(1):160. doi: 10.1186/s13054-016-1288-3.
5
Four phases of intravenous fluid therapy: a conceptual model.静脉输液治疗的四个阶段:一个概念模型
Br J Anaesth. 2014 Nov;113(5):740-7. doi: 10.1093/bja/aeu300. Epub 2014 Sep 9.
6
The role of venous return in critical illness and shock-part I: physiology.静脉回流在危重病和休克中的作用-第 1 部分:生理学。
Crit Care Med. 2013 Jan;41(1):255-62. doi: 10.1097/CCM.0b013e3182772ab6.
7
Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy.修正的 Starling 方程和跨血管液体交换的糖萼模型:一种改进的静脉输液治疗处方模式。
Br J Anaesth. 2012 Mar;108(3):384-94. doi: 10.1093/bja/aer515. Epub 2012 Jan 29.
8
Mortality after fluid bolus in African children with severe infection.严重感染非洲儿童输液后死亡率。
N Engl J Med. 2011 Jun 30;364(26):2483-95. doi: 10.1056/NEJMoa1101549. Epub 2011 May 26.
9
Effects of fluids on microvascular perfusion in patients with severe sepsis.严重脓毒症患者液体对微血管灌注的影响。
Intensive Care Med. 2010 Jun;36(6):949-55. doi: 10.1007/s00134-010-1843-3. Epub 2010 Mar 11.
10
Early goal-directed therapy in the treatment of severe sepsis and septic shock.早期目标导向治疗在严重脓毒症和脓毒性休克治疗中的应用
N Engl J Med. 2001 Nov 8;345(19):1368-77. doi: 10.1056/NEJMoa010307.