Yan Shao-Hua, Nai Wenqing, Peng LuShan, Wang Junpu
Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Department of Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Sci Rep. 2025 Mar 24;15(1):10107. doi: 10.1038/s41598-025-94594-x.
As a novel inflammatory marker, Systemic Immune-Inflammation Index (SII) has recently been recognized as a prognostic indicator for a variety of diseases including malignant cancers, coronary artery disease, hyperlipidemia, and hepatic steatosis. Carotenoids are a group of abundant lipid-soluble phytochemicals, and studies have suggested that they have antioxidant, antiapoptotic, and anti-inflammatory properties. However, a systematic analysis of the association between serum carotenoids and SII is still lacking. The purpose of this investigation was to explore the association between serum carotenoid concentration and SII. The cross-sectional investigation included general people (age ≥ 20) with complete information on SII and five different serum carotenoids (Trans-lycopene, β-carotene, α-carotene, lutein/zeaxanthin, and β-cryptoxanthin). Multivariate linear regression analyses were used to evaluate the association between serum carotenoids and SII among general people. The potential non-linear relationship was determined using threshold effect analysis and fitted smoothing curves. Subgroup analysis was performed to explore the potential stratified factors. 15903 participants were enrolled in our investigation. Based on multivariate linear regressions, the highest quartiles of serum carotenoids were found significantly associated with SII compared with the lowest quartiles. The results showed the negative association between SII and the concentration of five different serum carotenoids. According to the non-linear analysis, we found that there are non-linear relationships between β-carotene and trans-lycopene and SII in general people with an inflection point of 6.90 (log2-transformed, ug/dL) and 4.01 (log2-transformed, ug/dL), respectively. The results from subgroup analysis provide several potential moderating effects, such as race, current drinker, and age. This study revealed the relationship between the concentration of several serum carotenoids and SII across the general American population. Further prospective and longitude investigations are needed.
作为一种新型炎症标志物，全身免疫炎症指数（SII）最近被认为是包括恶性肿瘤、冠状动脉疾病、高脂血症和肝脂肪变性在内的多种疾病的预后指标。类胡萝卜素是一类丰富的脂溶性植物化学物质，研究表明它们具有抗氧化、抗凋亡和抗炎特性。然而，目前仍缺乏关于血清类胡萝卜素与SII之间关联的系统分析。本研究的目的是探讨血清类胡萝卜素浓度与SII之间的关联。横断面调查纳入了SII及五种不同血清类胡萝卜素（反式番茄红素、β-胡萝卜素、α-胡萝卜素、叶黄素/玉米黄质和β-隐黄质）信息完整的普通人群（年龄≥20岁）。采用多元线性回归分析评估普通人群中血清类胡萝卜素与SII之间的关联。使用阈值效应分析和拟合平滑曲线确定潜在的非线性关系。进行亚组分析以探索潜在的分层因素。我们的调查共纳入了15903名参与者。基于多元线性回归分析，发现血清类胡萝卜素最高四分位数与最低四分位数相比与SII显著相关。结果显示SII与五种不同血清类胡萝卜素浓度之间呈负相关。根据非线性分析，我们发现普通人群中β-胡萝卜素和反式番茄红素与SII之间存在非线性关系，拐点分别为6.90（对数2转换，微克/分升）和4.01（对数2转换，微克/分升）。亚组分析结果提供了几个潜在的调节效应，如种族、当前饮酒者和年龄。本研究揭示了美国普通人群中几种血清类胡萝卜素浓度与SII之间的关系。还需要进一步的前瞻性和纵向研究。
